Document Detail


Strategic applications of gene expression: from drug discovery/development to bedside.
MedLine Citation:
PMID:  23319288     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Gene expression is useful for identifying the molecular signature of a disease and for correlating a pharmacodynamic marker with the dose-dependent cellular responses to exposure of a drug. Gene expression offers utility to guide drug discovery by illustrating engagement of the desired cellular pathways/networks, as well as avoidance of acting on the toxicological pathways. Successful employment of gene-expression signatures in the later stages of drug development depends on their linkage to clinically meaningful phenotypic characteristics and requires a biologically meaningful mechanism combined with a stringent statistical rigor. Much of the success in clinical drug development is hinged on predefining the signature genes for their fitness for purposes of application. Specific examples are highlighted to illustrate the breadth and depth of the potential utility of gene-expression signatures in drug discovery and clinical development to targeted therapeutics at the bedside.
Authors:
Jane P F Bai; Alexander V Alekseyenko; Alexander Statnikov; I-Ming Wang; Peggy H Wong
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Review     Date:  2013-01-15
Journal Detail:
Title:  The AAPS journal     Volume:  15     ISSN:  1550-7416     ISO Abbreviation:  AAPS J     Publication Date:  2013 Apr 
Date Detail:
Created Date:  2013-04-05     Completed Date:  2013-10-22     Revised Date:  2014-01-23    
Medline Journal Info:
Nlm Unique ID:  101223209     Medline TA:  AAPS J     Country:  United States    
Other Details:
Languages:  eng     Pagination:  427-37     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Animals
Drug Discovery / methods*
Drug-Related Side Effects and Adverse Reactions
Gene Expression Profiling*
Gene Expression Regulation / drug effects*
Gene Regulatory Networks
Genetic Markers
Genetic Predisposition to Disease
Genetic Testing*
Humans
Individualized Medicine
Molecular Targeted Therapy
Patient Safety
Patient Selection
Phenotype
Predictive Value of Tests
Translational Medical Research / methods*
Grant Support
ID/Acronym/Agency:
1 R01 LM011179-01/LM/NLM NIH HHS
Chemical
Reg. No./Substance:
0/Genetic Markers
Comments/Corrections

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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