| Strain and torsion quantification in mouse hearts under dobutamine stimulation using 2D multiphase MR DENSE. | |
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MedLine Citation:
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PMID: 20740659 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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In this study, a 2D multiphase magnetic resonance displacement encoding with stimulated echoes (DENSE) imaging and analysis method was developed for direct quantification of Lagrangian strain in the mouse heart. Using the proposed method, <10 ms temporal resolution and 0.56 mm in-plane resolution were achieved. A validation study that compared strain calculation by displacement encoding with stimulated echoes and by magnetic resonance tagging showed high correlation between the two methods (R(2) > 0.80). Regional ventricular wall strain and twist were characterized in mouse hearts at baseline and under dobutamine stimulation. Dobutamine stimulation induced significant increase in radial and circumferential strains and torsion at peak systole. A rapid untwisting was also observed during early diastole. This work demonstrates the capability of characterizing cardiac functional response to dobutamine stimulation in the mouse heart using 2D multiphase magnetic resonance displacement encoding with stimulated echoes. |
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Authors:
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Jia Zhong; Xin Yu |
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Publication Detail:
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Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't Date: 2010-08-25 |
Journal Detail:
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Title: Magnetic resonance in medicine : official journal of the Society of Magnetic Resonance in Medicine / Society of Magnetic Resonance in Medicine Volume: 64 ISSN: 1522-2594 ISO Abbreviation: Magn Reson Med Publication Date: 2010 Nov |
Date Detail:
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Created Date: 2010-10-28 Completed Date: 2011-03-08 Revised Date: 2012-02-24 |
Medline Journal Info:
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Nlm Unique ID: 8505245 Medline TA: Magn Reson Med Country: United States |
Other Details:
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Languages: eng Pagination: 1315-22 Citation Subset: IM |
Copyright Information:
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Copyright © 2010 Wiley-Liss, Inc. |
Affiliation:
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Department of Biomedical Engineering, Case Western Reserve University, Cleveland, Ohio, USA. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Algorithms* Animals Cardiotonic Agents / diagnostic use Dobutamine / diagnostic use* Elastic Modulus Elasticity Imaging Techniques / methods* Image Enhancement / methods Image Interpretation, Computer-Assisted / methods* Magnetic Resonance Imaging, Cine / methods* Male Mice Mice, Inbred C57BL Reproducibility of Results Sensitivity and Specificity Torque Ventricular Function, Left / physiology* |
| Grant Support | |
ID/Acronym/Agency:
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R01 HL073315-01A1/HL/NHLBI NIH HHS; R01 HL073315-02/HL/NHLBI NIH HHS; R01 HL073315-03/HL/NHLBI NIH HHS; R01 HL073315-04/HL/NHLBI NIH HHS; R01 HL073315-05/HL/NHLBI NIH HHS; R01 HL073315-06A2/HL/NHLBI NIH HHS; R01 HL073315-07/HL/NHLBI NIH HHS; R01 HL073315-08/HL/NHLBI NIH HHS; R01 HL086935-01/HL/NHLBI NIH HHS; R01 HL086935-02/HL/NHLBI NIH HHS; R01 HL086935-03/HL/NHLBI NIH HHS; R01 HL086935-03W1/HL/NHLBI NIH HHS; R01 HL086935-04/HL/NHLBI NIH HHS; R01 HL73315/HL/NHLBI NIH HHS; R01 HL86935/HL/NHLBI NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/Cardiotonic Agents; 34368-04-2/Dobutamine |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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