Document Detail


Strain-based estimation of time-dependent transmural myocardial architecture in the ovine heart.
MedLine Citation:
PMID:  20821245     Owner:  NLM     Status:  In-Data-Review    
Abstract/OtherAbstract:
Left ventricular myofibers are connected by an extensive extracellular collagen matrix to form myolaminar sheets. Histological cardiac tissue studies have previously observed a pleated transmural distribution of sheets in the ovine heart, alternating sign of the sheet angle from epicardium to endocardium. The present study investigated temporal variations in myocardial fiber and sheet architecture during the cardiac cycle. End-diastolic histological measurements made at subepicardium, midwall, and subendocardium at an anterior-basal and a lateral-equatorial region of the ovine heart, combined with transmural myocardial Lagrangian strains, showed that the sheet angle but not the fiber angle varied temporally throughout the cardiac cycle. The magnitude of the sheet angle decreased during systole at all transmural depths at the anterior-basal site and at midwall and subendocardium depths at the lateral-equatorial site, making the sheets more parallel to the radial axis. These results support a previously suggested accordion-like wall-thickening mechanism of the myocardial sheets.
Authors:
Katarina Kindberg; Charlotte Oom; Neil B Ingels; Matts Karlsson
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Publication Detail:
Type:  Journal Article     Date:  2010-09-07
Journal Detail:
Title:  Biomechanics and modeling in mechanobiology     Volume:  10     ISSN:  1617-7940     ISO Abbreviation:  Biomech Model Mechanobiol     Publication Date:  2011 Jul 
Date Detail:
Created Date:  2011-06-27     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101135325     Medline TA:  Biomech Model Mechanobiol     Country:  Germany    
Other Details:
Languages:  eng     Pagination:  521-8     Citation Subset:  IM; S    
Affiliation:
Department of Management and Engineering, Linköping University, 581 83, Linköping, Sweden, katarina.kindberg@liu.se.
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