Document Detail

Strain analysis in patients with severe aortic stenosis and preserved left ventricular ejection fraction undergoing surgical valve replacement.
MedLine Citation:
PMID:  19726436     Owner:  NLM     Status:  MEDLINE    
AIMS: To evaluate myocardial multidirectional strain and strain rate (S-and-SR) in severe aortic stenosis (AS) patients with preserved left ventricular (LV) ejection fraction (EF), using two-dimensional speckle-tracking strain imaging (2D-STI). The long-term effect of aortic valve replacement (AVR) on S-and-SR was also evaluated.
METHODS AND RESULTS: Changes in LV radial, circumferential, and longitudinal S-and-SR were evaluated in 73 severe AS patients (65 +/- 13 years; aortic valve area 0.8 +/- 0.2 cm2) with preserved LVEF (61 +/- 11%), before and 17 months after AVR. Strain and strain rate data were compared with data from 40 controls (20 healthy individuals and 20 patients with LV hypertrophy) matched by age, gender, body surface area, and LVEF. Compared with controls, severe AS patients had significantly decreased values of LV S-and-SR in the radial (33.1 +/- 14.8%, P = 0.2; 1.7 +/- 0.5 s(-1), P = 0.003), circumferential (-15.2 +/- 5.0%, P = 0.001; -0.9 +/- 0.3 s(-1), P < 0.0001), and longitudinal (-14.6 +/- 4.1%, P < 0.0001; -0.8 +/- 0.2 s(-1), P < 0.0001) directions. At 17 months after AVR, LV S-and-SR significantly improved in all the three directions, whereas LVEF remained unchanged (60 +/- 12%, P = 0.7).
CONCLUSION: In severe AS patients, impaired LV S-and-SR existed although LVEF was preserved. After AVR, a significant S-and-SR improvement in all the three directions was observed. These subtle changes in LV contractility can be detected by 2D-STI.
Victoria Delgado; Laurens F Tops; Rutger J van Bommel; Frank van der Kley; Nina Ajmone Marsan; Robert J Klautz; Michel I M Versteegh; Eduard R Holman; Martin J Schalij; Jeroen J Bax
Related Documents :
6616506 - Early angiographic features of right ventricular endomyocardial fibrosis.
15124926 - Induction of heat shock protein 72 in the failing heart is attenuated after an exposure...
7977096 - Left ventricular dilatation and multivessel coronary artery disease on thallium-201 spe...
18677436 - Clinical, angiographic and cardiovascular magnetic resonance findings in consecutive pa...
19940276 - Genetically reduced soluble epoxide hydrolase activity and risk of stroke and other car...
2632826 - Long-term prognostic assessment of ventricular tachycardia with respect to sudden death...
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  European heart journal     Volume:  30     ISSN:  1522-9645     ISO Abbreviation:  Eur. Heart J.     Publication Date:  2009 Dec 
Date Detail:
Created Date:  2009-12-16     Completed Date:  2011-01-11     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8006263     Medline TA:  Eur Heart J     Country:  England    
Other Details:
Languages:  eng     Pagination:  3037-47     Citation Subset:  IM    
Department of Cardiology and Cardiothoracic Surgery, Leiden University Medical Center, Albinusdreef 2, 2333 ZA, Leiden, The Netherlands.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Analysis of Variance
Aortic Valve Stenosis / physiopathology*,  surgery
Heart Rate / physiology
Heart Valve Prosthesis
Heart Valve Prosthesis Implantation
Myocardial Contraction / physiology
Stroke Volume / physiology*
Ventricular Function, Left / physiology*

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  Retinal drusen: harbingers of age, safe havens for trouble.
Next Document:  Clinical impact of thrombectomy in acute ST-elevation myocardial infarction: an individual patient-d...