Document Detail

Strain Release in Organic Photonic Nanoparticles for Protease Sensing.
MedLine Citation:
PMID:  22489929     Owner:  NLM     Status:  Publisher    
Proteases are overexpressed in most cancers and proteolytic activity has been shown to be a viable marker for cancer imaging in vivo. Herein, we describe the synthesis of luminescence-quenched shell cross-linked nanoparticles as photonic nanoprobes for protease sensing. Protease sensing scheme is based on a "turn-on" mechanism where the protease cleaves peptide cross-linkers of the fluorescence-quenched shell cross-linked NP (OFF state) leading to a highly emissive non-cross linked NP (ON state). The cross-linked particles can be strained by exposure to a good solvent and proteolysis allows for particle expansion (swelling) and a recovery of the luminescence.
Carlos Cordovilla; Timothy M Swager
Related Documents :
11964169 - Mutational analysis of the two zinc-binding sites of the bacillus cereus 569/h/9 metall...
2831219 - Synergistic binding of ligands to angiotensin-converting enzyme.
12445779 - Conservation of helical structure contributes to functional metal ion interactions in t...
17399739 - Crystal structure of the zinc-binding transport protein znua from escherichia coli reve...
10694579 - The interaction of nitric oxide (no) with the yeast transcription factor ace1: a model ...
21053939 - The second-shell metal ligands of human arginase affect coordination of the nucleophile...
20039879 - Espm2 is a rhoa guanine nucleotide exchange factor.
20455089 - Structural aspects of adherens junctions and desmosomes.
23711919 - Synthesis and structure-activity relationship of pyripyropene a derivatives as potent a...
Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2012-4-10
Journal Detail:
Title:  Journal of the American Chemical Society     Volume:  -     ISSN:  1520-5126     ISO Abbreviation:  -     Publication Date:  2012 Apr 
Date Detail:
Created Date:  2012-4-11     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  7503056     Medline TA:  J Am Chem Soc     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Department of Chemistry, Massachusetts Institute of Technology , Cambridge, Massachusetts 02139, United States.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  Are bruxism and the bite causally related?
Next Document:  Telehealth-A Change in a Practice Model in Oncology.