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Strain Rate Imaging Predicts the Attenuation of Left Ventricular Remodeling Induced by Ischemic Post-Conditioning After Myocardial Infarction in Mice.
MedLine Citation:
PMID:  21737599     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
BACKGROUND: -Systolic strain rate (SR) has been shown to correlate with the transmural extent of myocardial infarction (MI). Ischemic post-conditioning (PC) decreases MI size. We aimed to determine whether SR may predict the reduction of left ventricular (LV) remodeling induced by PC in a murine model of ischemia-reperfusion. METHODS AND RESULTS: -C57BL6 mice underwent 60 min of left coronary artery occlusion followed by reperfusion. PC consisted of three cycles of 1 min of reperfusion and 1 min of ischemia performed immediately after reperfusion. After 24 hours of reperfusion, a first subset of mice was euthanized for determination of infarct size. An additional subset of mice underwent 3 months of reperfusion. Echocardiography and SR were serially assessed at baseline, 3 days and 1, 2, 3 months after reperfusion. PC decreased the infarct size and increased SR values within infarcted segments as soon as 24 hours after reperfusion as compared to controls (14±1 vs. 6±1s(-1), p<0.001). Systolic SR was correlated with MI size assessed by the area of infarction/area at risk (r=-0.88, p<0.001). At 3 months, PC improved LV ejection fraction (55±4 vs. 45±3%; p<0.05) and decreased LV dimensions as compared with controls. Strain rate at day 3 correlated with LV ejection fraction (0.75; p<0.001), end-systolic (r=-0.75; p=0.001) and end-diastolic volumes (r=-0.70; p<0.001) at month 3. CONCLUSIONS: -In this murine model of MI, SR accurately assessed the reduction in MI size induced by PC early after reperfusion and the subsequent reduction of LV remodeling.
Authors:
Hélène Thibault; Ludovic Gomez; Cyrille Bergerot; Lionel Augeul; Marielle Scherrer-Crosbie; Michel Ovize; Geneviève Derumeaux
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2011-7-7
Journal Detail:
Title:  Circulation. Cardiovascular imaging     Volume:  -     ISSN:  1942-0080     ISO Abbreviation:  -     Publication Date:  2011 Jul 
Date Detail:
Created Date:  2011-7-8     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101479935     Medline TA:  Circ Cardiovasc Imaging     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Affiliation:
1 U1060-CARMEN, Cardioprotection and Hôpital Louis Pradel, Hospices Civils de Lyon, Lyon, France;
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