Document Detail

Straddling mitral and tricuspid valves: morphologic differences and developmental backgrounds.
MedLine Citation:
PMID:  7081077     Owner:  NLM     Status:  MEDLINE    
The anatomy of 25 hearts with a straddling mitral or tricuspid valve, or both, is described. Malalignment of atrial and ventricular septa is an essential feature of a straddling tricuspid valve, creating an inlet septal defect. Across this defect, the tricuspid valve straddles into the opposite (left ventricular) chamber, where it is separated from the mitral valve by a posterior muscular ridge, the posteromedial muscle. A straddling mitral valve requires an infundibular septal defect, predominantly of the malalignment type, in which the anterior part of the ventricular septum deviates to the left of the infundibular septum. The mitral valve straddles into the opposite (right ventricular) chamber, anterior to the trabecula septomarginalis. From normal developmental stages, it is concluded that valve formation takes place only after completion of ventricular septation. Any malformation of the valves is therefore considered to be superimposed on a primary malformation of the septum. The ventricular septum itself develops from three different components. Malseptation in the inlet portion of the embryonic heart lead to the characteristic septal malformation seen in straddling tricuspid valve. Malseptation in the outlet portion may lead to the septal malformation that characterizes straddling mitral valve.
A C Wenink; A C Gittenberger-de Groot
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  The American journal of cardiology     Volume:  49     ISSN:  0002-9149     ISO Abbreviation:  Am. J. Cardiol.     Publication Date:  1982 Jun 
Date Detail:
Created Date:  1982-07-22     Completed Date:  1982-07-22     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  0207277     Medline TA:  Am J Cardiol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  1959-71     Citation Subset:  AIM; IM    
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MeSH Terms
Child, Preschool
Heart Septal Defects, Ventricular / embryology
Infant, Newborn
Mitral Valve / abnormalities*,  embryology
Tricuspid Valve / abnormalities*,  embryology

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