| Storage time of blood products and transfusion-related acute lung injury. | |
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MedLine Citation:
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PMID: 21950582 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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BACKGROUND: Besides white blood cell antibodies in plasma-rich products, another cause of transfusion-related acute lung injury (TRALI) could be release of biologically active substances during storage of cellular blood products. We aimed to investigate the association of storage time and risk of TRALI for different product types. STUDY DESIGN AND METHODS: We compared storage time of blood products transfused within 6 hours before the onset of TRALI to storage time of a representative sample of all blood products transfused in the Netherlands. Generalized linear models were used to correct for confounding variables. RESULTS: Platelets (PLTs) in plasma transfused to TRALI patients were stored for 0.7 (95% confidence interval [CI], 0.073 to 1.3) days longer than those transfused to controls. The relative risk of TRALI, after receiving PLTs stored for 4 or 5 days, compared to 3 days or less, was 5.8 (95% CI, 0.99 to 110) and increased to 6.3 (95% CI, 1.1 to 118) after more than 5 days (i.e., 6 or 7 days). CONCLUSIONS: While longer storage of buffy coat-derived PLTs was associated with an increased risk of TRALI, storage of plasma for up to 2 years and red blood cells for up to 35 days was not associated with the risk of TRALI. |
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Authors:
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Rutger A Middelburg; Barbara Borkent; Mart Jansen; Leo M G van de Watering; Johanna C Wiersum-Osselton; Martin R Schipperus; Erik A M Beckers; Ernest Briët; Johanna G van der Bom |
Publication Detail:
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Type: JOURNAL ARTICLE Date: 2011-9-26 |
Journal Detail:
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Title: Transfusion Volume: - ISSN: 1537-2995 ISO Abbreviation: - Publication Date: 2011 Sep |
Date Detail:
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Created Date: 2011-9-28 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 0417360 Medline TA: Transfusion Country: - |
Other Details:
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Languages: ENG Pagination: - Citation Subset: - |
Copyright Information:
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© 2011 American Association of Blood Banks. |
Affiliation:
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From the Department of Clinical Epidemiology, Leiden University Medical Center, and Sanquin-LUMC Jon J. van Rood Center for Clinical Transfusion Research, Leiden, The Netherlands; UMC Utrecht, Julius Center for Health Sciences and Primary Care, Utrecht, The Netherlands; TRIP (Transfusion Reactions in Patients) Dutch National Hemovigilance Office, The Hague, The Netherlands; and Internal Medicine-Hematology, Maastricht University Medical Center, Maastricht, The Netherlands. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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