Document Detail

Stopping the control arm in response to the DSMB: mother's choice of HIV prophylaxis during breastfeeding in the BAN Study.
MedLine Citation:
PMID:  22041453     Owner:  NLM     Status:  MEDLINE    
The Data and Safety Monitoring Board (DSMB) for the Breastfeeding, Antiretrovirals, and Nutrition study, a clinical trial aimed to prevent postnatal HIV transmission, recommended halting randomization to the enhanced standard-of-care (control) arm. The 67 mother-infant pairs on the control arm and less than 21 weeks postpartum at the time of the DSMB recommendation were read a script informing them of the DSMB decision and offering them the maternal or infant antiretroviral interventions for the remainder of the 28-week breastfeeding period. This paper describes the BAN study response to the DSMB decision and what the women on the control arm chose, when given a choice to start the maternal or infant antiretroviral interventions.
Charity Chavula; Dustin Long; Enalla Mzembe; Dumbani Kayira; Charles Chasela; Michael G Hudgens; Mina Hosseinipour; Caroline C King; Sascha Ellington; Margret Chigwenembe; Denise J Jamieson; Charles van der Horst
Related Documents :
21980943 - Self-report versus medical record - perinatal factors in a study of infant leukaemia: a...
25179383 - Neonatal umbilical cord myiasis in new jersey.
2935553 - Persistence of fetal zone function in the infant rhesus monkey adrenal gland.
Publication Detail:
Type:  Comparative Study; Journal Article; Randomized Controlled Trial; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.; Research Support, U.S. Gov't, P.H.S.     Date:  2011-10-25
Journal Detail:
Title:  Contemporary clinical trials     Volume:  33     ISSN:  1559-2030     ISO Abbreviation:  Contemp Clin Trials     Publication Date:  2012 Jan 
Date Detail:
Created Date:  2012-01-09     Completed Date:  2012-05-29     Revised Date:  2014-09-08    
Medline Journal Info:
Nlm Unique ID:  101242342     Medline TA:  Contemp Clin Trials     Country:  United States    
Other Details:
Languages:  eng     Pagination:  55-9     Citation Subset:  IM    
Copyright Information:
Published by Elsevier Inc.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Anti-HIV Agents / therapeutic use*
Breast Feeding*
Follow-Up Studies
HIV Infections / prevention & control*,  transmission
Infant, Newborn
Infectious Disease Transmission, Vertical / prevention & control*
Milk, Human / virology*
Retrospective Studies
Young Adult
Grant Support
2-D43 TW01039-06/TW/FIC NIH HHS; P30 AI050410/AI/NIAID NIH HHS; P30 AI050410-15/AI/NIAID NIH HHS; P30-AI50410/AI/NIAID NIH HHS; R24 TW00798/TW/FIC NIH HHS; SIP 13-01 U48-CCU409660-09//PHS HHS; SIP 22-09 U48-DP001944-01/DP/NCCDPHP CDC HHS; SIP 26-04 U48-DP000059-01/DP/NCCDPHP CDC HHS
Reg. No./Substance:
0/Anti-HIV Agents

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  A Repeated Coiled-Coil Interruption in the Escherichiacoli Condensin MukB.
Next Document:  Oxidants, metabolism, and stem cell biology.