| Stop-flow lithography to generate cell-laden microgel particles. | |
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MedLine Citation:
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PMID: 18584079 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Encapsulating cells within hydrogels is important for generating three-dimensional (3D) tissue constructs for drug delivery and tissue engineering. This paper describes, for the first time, the fabrication of large numbers of cell-laden microgel particles using a continuous microfluidic process called stop-flow lithography (SFL). Prepolymer solution containing cells was flowed through a microfluidic device and arrays of individual particles were repeatedly defined using pulses of UV light through a transparency mask. Unlike photolithography, SFL can be used to synthesize microgel particles continuously while maintaining control over particle size, shape and anisotropy. Therefore, SFL may become a useful tool for generating cell-laden microgels for various biomedical applications. |
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Authors:
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Priyadarshi Panda; Shamsher Ali; Edward Lo; Bong Geun Chung; T Alan Hatton; Ali Khademhosseini; Patrick S Doyle |
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Publication Detail:
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Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S. Date: 2008-05-22 |
Journal Detail:
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Title: Lab on a chip Volume: 8 ISSN: 1473-0197 ISO Abbreviation: Lab Chip Publication Date: 2008 Jul |
Date Detail:
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Created Date: 2008-06-27 Completed Date: 2008-09-12 Revised Date: 2011-05-13 |
Medline Journal Info:
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Nlm Unique ID: 101128948 Medline TA: Lab Chip Country: England |
Other Details:
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Languages: eng Pagination: 1056-61 Citation Subset: IM |
Affiliation:
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Department of Chemical Engineering, Massachusetts Institute of Technology, Cambridge, MA 02139, USA. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Cell Survival / drug effects Cells / cytology, drug effects, metabolism* Hydrogels / metabolism*, pharmacology Mice Microfluidic Analytical Techniques / methods* NIH 3T3 Cells Polyethylene Glycols / metabolism, pharmacology Tissue Engineering |
| Grant Support | |
ID/Acronym/Agency:
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R01 HL092836-01A1/HL/NHLBI NIH HHS; R21 EB007249-02/EB/NIBIB NIH HHS; RL1 DE019024-02/DE/NIDCR NIH HHS; RL1 DE019024-03/DE/NIDCR NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/Hydrogels; 0/Polyethylene Glycols; 0/poly(ethylene glycol)diacrylate |
| Comments/Corrections | |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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