| Stool microflora in extremely low birthweight infants. | |
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MedLine Citation:
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PMID: 10212075 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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AIM: To serially characterise aerobic and anaerobic stool microflora in extremely low birthweight infants and to correlate colonisation patterns with clinical risk factors. METHODS: Stool specimens from 29 infants of birthweight <1000 g were collected on days 10, 20, and 30 after birth. Quantitative aerobic and anaerobic cultures were performed. RESULTS: By day 30, predominant species were Enterococcus faecalis, Escherichia coli, Staphylococcus epidermidis, Enterbacter cloacae, Klebsiella pneumoniae, and Staphylococcus haemolyticus. Lactobacillus and Bifidobacteria spp were identified in only one infant. In breast milk fed (but not in formula fed) infants, the total number of bacterial species/stool specimen increased significantly with time (2.50 (SE 0.34) on day 10; 3.13 (0.38) on day 20; 4.27 (0.45) on day 30) as did quantitative bacterial counts; Gram negative species accounted for most of the increase. On day 30, significant inverse correlations were found between days of previous antibiotic treatment and number of bacterial species (r=0.491) and total organisms/g of stool (r=0.482). Gestational age, birthweight, maternal antibiotic or steroid treatment, prolonged rupture of the membranes, and mode of delivery did not seem to affect colonisation patterns. CONCLUSIONS: The gut of extremely low birthweight infants is colonised by a paucity of bacterial species. Breast milking and reduction of antibiotic exposure are critical to increasing fecal microbial diversity. |
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Authors:
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I H Gewolb; R S Schwalbe; V L Taciak; T S Harrison; P Panigrahi |
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Publication Detail:
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Type: Comparative Study; Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S. |
Journal Detail:
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Title: Archives of disease in childhood. Fetal and neonatal edition Volume: 80 ISSN: 1359-2998 ISO Abbreviation: Arch. Dis. Child. Fetal Neonatal Ed. Publication Date: 1999 May |
Date Detail:
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Created Date: 2000-03-29 Completed Date: 2000-03-29 Revised Date: 2009-11-18 |
Medline Journal Info:
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Nlm Unique ID: 9501297 Medline TA: Arch Dis Child Fetal Neonatal Ed Country: ENGLAND |
Other Details:
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Languages: eng Pagination: F167-73 Citation Subset: AIM; IM |
Affiliation:
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Division of Neonatology-UMMS Rm N5W68, Department of Pediatrics, University of Maryland School of Medicine, Baltimore, MD 21201-1554, USA. igewolb@peds05.ab.umd.edu |
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| MeSH Terms | |
Descriptor/Qualifier:
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Anti-Bacterial Agents
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administration & dosage Bacteria, Aerobic / isolation & purification* Bacteria, Anaerobic / isolation & purification* Bifidobacterium / isolation & purification Bottle Feeding Breast Feeding Cohort Studies Enterobacter cloacae / isolation & purification Enterococcus faecalis / isolation & purification Escherichia coli / isolation & purification Feces / microbiology* Humans Infant, Newborn Infant, Very Low Birth Weight* Klebsiella pneumoniae / isolation & purification Lactobacillus / isolation & purification Staphylococcus / isolation & purification Staphylococcus epidermidis / isolation & purification |
| Grant Support | |
ID/Acronym/Agency:
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HD-29735/HD/NICHD NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/Anti-Bacterial Agents |
| Comments/Corrections | |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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