Document Detail


Stool microflora in extremely low birthweight infants.
MedLine Citation:
PMID:  10212075     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
AIM: To serially characterise aerobic and anaerobic stool microflora in extremely low birthweight infants and to correlate colonisation patterns with clinical risk factors. METHODS: Stool specimens from 29 infants of birthweight <1000 g were collected on days 10, 20, and 30 after birth. Quantitative aerobic and anaerobic cultures were performed. RESULTS: By day 30, predominant species were Enterococcus faecalis, Escherichia coli, Staphylococcus epidermidis, Enterbacter cloacae, Klebsiella pneumoniae, and Staphylococcus haemolyticus. Lactobacillus and Bifidobacteria spp were identified in only one infant. In breast milk fed (but not in formula fed) infants, the total number of bacterial species/stool specimen increased significantly with time (2.50 (SE 0.34) on day 10; 3.13 (0.38) on day 20; 4.27 (0.45) on day 30) as did quantitative bacterial counts; Gram negative species accounted for most of the increase. On day 30, significant inverse correlations were found between days of previous antibiotic treatment and number of bacterial species (r=0.491) and total organisms/g of stool (r=0.482). Gestational age, birthweight, maternal antibiotic or steroid treatment, prolonged rupture of the membranes, and mode of delivery did not seem to affect colonisation patterns. CONCLUSIONS: The gut of extremely low birthweight infants is colonised by a paucity of bacterial species. Breast milking and reduction of antibiotic exposure are critical to increasing fecal microbial diversity.
Authors:
I H Gewolb; R S Schwalbe; V L Taciak; T S Harrison; P Panigrahi
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Publication Detail:
Type:  Comparative Study; Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Archives of disease in childhood. Fetal and neonatal edition     Volume:  80     ISSN:  1359-2998     ISO Abbreviation:  Arch. Dis. Child. Fetal Neonatal Ed.     Publication Date:  1999 May 
Date Detail:
Created Date:  2000-03-29     Completed Date:  2000-03-29     Revised Date:  2009-11-18    
Medline Journal Info:
Nlm Unique ID:  9501297     Medline TA:  Arch Dis Child Fetal Neonatal Ed     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  F167-73     Citation Subset:  AIM; IM    
Affiliation:
Division of Neonatology-UMMS Rm N5W68, Department of Pediatrics, University of Maryland School of Medicine, Baltimore, MD 21201-1554, USA. igewolb@peds05.ab.umd.edu
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MeSH Terms
Descriptor/Qualifier:
Anti-Bacterial Agents / administration & dosage
Bacteria, Aerobic / isolation & purification*
Bacteria, Anaerobic / isolation & purification*
Bifidobacterium / isolation & purification
Bottle Feeding
Breast Feeding
Cohort Studies
Enterobacter cloacae / isolation & purification
Enterococcus faecalis / isolation & purification
Escherichia coli / isolation & purification
Feces / microbiology*
Humans
Infant, Newborn
Infant, Very Low Birth Weight*
Klebsiella pneumoniae / isolation & purification
Lactobacillus / isolation & purification
Staphylococcus / isolation & purification
Staphylococcus epidermidis / isolation & purification
Grant Support
ID/Acronym/Agency:
HD-29735/HD/NICHD NIH HHS
Chemical
Reg. No./Substance:
0/Anti-Bacterial Agents
Comments/Corrections

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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