Document Detail


Stoichiometric expression of MMP-2/TIMP-2 in benign and malignant tumours of the salivary gland.
MedLine Citation:
PMID:  25412957     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
The aim of this study was to determine the expression of matrix metalloproteinase 2 (MMP-2) and tissue inhibitors of matrix metalloproteinase 2 (TIMP-2) and the MMP-2/TIMP-2 expression ratio in salivary gland tumours (SGTs). Forty-three FFPE SGTs were prepared for antibody processing to MMP-2 and TIMP-2. Two investigators utilizing Sinicrope's method scored the uptake of immuno-stains. Cytoplasmic staining was considered as positive. Data was analysed using SPSS version 20. The significance level was set at p < 0.05. In benign SGTs, the mean score for MMP-2 was not significantly lower than that of TIMP-2 (p = 0.37). However, the mean scores for MMP-2 stain intensity and proportion were significantly higher in malignant than benign SGTs (p = 0.01 and p = 0.02 respectively). There was no significant difference in the mean MMP-2/TIMP-2 expression ratio of the malignant SGTs according to histological grade and histogenesis (p = 0.4 and p = 0.19 respectively). The MMP-2/TIMP-2 expression ratio has a higher prognostic value than the separate expressions of MMP-2 and TIMP-2.
Authors:
Bamidele Kolude; Akinyele Olumuyiwa Adisa; Ahmed Oluwatoyin Lawal; Bukola Folasade Adeyemi; Akindayo Olufunto Akinyamoju
Related Documents :
17549507 - Characterization of a new sumo-1 nuclear body (snb) enriched in pcreb, cbp, c-jun in ne...
18603327 - Regulation of human beta-defensin-2 by mycobacterium bovis bacillus calmette-guérin (b...
16552807 - Interleukin-1 beta up-regulates tissue inhibitor of matrix metalloproteinase-1 mrna and...
24143167 - Muc1 regulates expression of multiple micrornas involved in pancreatic tumor progressio...
25161887 - Erα upregulates phd3 to ameliorate hif-1 induced fibrosis and inflammation in adipose ...
15994927 - Bcl-2 promotes invasion and lung metastasis by inducing matrix metalloproteinase-2.
Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2014-11-21
Journal Detail:
Title:  Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine     Volume:  -     ISSN:  1423-0380     ISO Abbreviation:  Tumour Biol.     Publication Date:  2014 Nov 
Date Detail:
Created Date:  2014-11-21     Completed Date:  -     Revised Date:  2014-11-21    
Medline Journal Info:
Nlm Unique ID:  8409922     Medline TA:  Tumour Biol     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  Prognostic significance of lymph node ratio in esophageal cancer.
Next Document:  Clinicopathological and cellular signature of PAK1 in human bladder cancer.