Document Detail


Stochastic models of lymphocyte proliferation and death.
MedLine Citation:
PMID:  20941358     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Quantitative understanding of the kinetics of lymphocyte proliferation and death upon activation with an antigen is crucial for elucidating factors determining the magnitude, duration and efficiency of the immune response. Recent advances in quantitative experimental techniques, in particular intracellular labeling and multi-channel flow cytometry, allow one to measure the population structure of proliferating and dying lymphocytes for several generations with high precision. These new experimental techniques require novel quantitative methods of analysis. We review several recent mathematical approaches used to describe and analyze cell proliferation data. Using a rigorous mathematical framework, we show that two commonly used models that are based on the theories of age-structured cell populations and of branching processes, are mathematically identical. We provide several simple analytical solutions for a model in which the distribution of inter-division times follows a gamma distribution and show that this model can fit both simulated and experimental data. We also show that the estimates of some critical kinetic parameters, such as the average inter-division time, obtained by fitting models to data may depend on the assumed distribution of inter-division times, highlighting the challenges in quantitative understanding of cell kinetics.
Authors:
Anton Zilman; Vitaly V Ganusov; Alan S Perelson
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Research Support, U.S. Gov't, Non-P.H.S.; Review     Date:  2010-09-30
Journal Detail:
Title:  PloS one     Volume:  5     ISSN:  1932-6203     ISO Abbreviation:  PLoS ONE     Publication Date:  2010  
Date Detail:
Created Date:  2010-10-13     Completed Date:  2011-02-18     Revised Date:  2013-07-03    
Medline Journal Info:
Nlm Unique ID:  101285081     Medline TA:  PLoS One     Country:  United States    
Other Details:
Languages:  eng     Pagination:  -     Citation Subset:  IM    
Affiliation:
Theoretical Biology and Biophysics Group, Theoretical Division, Los Alamos National Laboratory, Los Alamos, New Mexico, United States of America. zilmana@lanl.gov
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MeSH Terms
Descriptor/Qualifier:
Animals
Cell Death
Cell Proliferation*
Humans
Kinetics
Lymphocyte Activation
Lymphocytes / chemistry,  cytology*,  immunology
Mathematical Computing
Models, Biological
Grant Support
ID/Acronym/Agency:
P01 AI071195-01/AI/NIAID NIH HHS; R01-RR06555/RR/NCRR NIH HHS; R37-AI28433/AI/NIAID NIH HHS
Comments/Corrections

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