Document Detail

Stochastic generation of gamma-band activity in primary visual cortex of awake and anesthetized monkeys.
MedLine Citation:
PMID:  23035096     Owner:  NLM     Status:  MEDLINE    
Oscillatory neural activity within the gamma band (25-90 Hz) is generally thought to be able to provide a timing signal for harmonizing neural computations across different brain regions. Using time-frequency analyses of the dynamics of gamma-band activity in the local field potentials recorded from monkey primary visual cortex, we found identical temporal characteristics of gamma activity in both awake and anesthetized brain states, including large variability of peak frequency, brief oscillatory epochs (<100 ms on average), and stochastic statistics of the incidence and duration of oscillatory events. These findings indicate that gamma-band activity is temporally unstructured and is inherently a stochastic signal generated by neural networks. This idea was corroborated further by our neural-network simulations. Our results suggest that gamma-band activity is too random to serve as a clock signal for synchronizing neuronal responses in awake as in anesthetized monkeys. Instead, gamma-band activity is more likely to be filtered neuronal network noise. Its mean frequency changes with global state and is reduced under anesthesia.
Dajun Xing; Yutai Shen; Samuel Burns; Chun-I Yeh; Robert Shapley; Wu Li
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Publication Detail:
Type:  Comparative Study; Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  The Journal of neuroscience : the official journal of the Society for Neuroscience     Volume:  32     ISSN:  1529-2401     ISO Abbreviation:  J. Neurosci.     Publication Date:  2012 Oct 
Date Detail:
Created Date:  2012-10-04     Completed Date:  2013-01-17     Revised Date:  2013-08-29    
Medline Journal Info:
Nlm Unique ID:  8102140     Medline TA:  J Neurosci     Country:  United States    
Other Details:
Languages:  eng     Pagination:  13873-80a     Citation Subset:  IM    
State Key Laboratory of Cognitive Neuroscience and Learning, Beijing Normal University, Beijing 100875, China.
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MeSH Terms
Anesthesia* / psychology
Biological Clocks / physiology*
Brain Waves / physiology*
Electroencephalography Phase Synchronization / physiology*
Macaca fascicularis
Macaca mulatta
Nerve Net / physiology*
Photic Stimulation
Stochastic Processes
Time Factors
Visual Cortex / physiology*
Visual Perception / physiology
Wakefulness / physiology*
Grant Support
R01 EY-01472/EY/NEI NIH HHS; T32-EY007158/EY/NEI NIH HHS

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