Document Detail

Stochastic mechanisms of cell fate specification that yield random or robust outcomes.
MedLine Citation:
PMID:  20590453     Owner:  NLM     Status:  MEDLINE    
Although cell fate specification is tightly controlled to yield highly reproducible results and avoid extreme variation, developmental programs often incorporate stochastic mechanisms to diversify cell types. Stochastic specification phenomena are observed in a wide range of species and an assorted set of developmental contexts. In bacteria, stochastic mechanisms are utilized to generate transient subpopulations capable of surviving adverse environmental conditions. In vertebrate, insect, and worm nervous systems, stochastic fate choices are used to increase the repertoire of sensory and motor neuron subtypes. Random fate choices are also integrated into developmental programs controlling organogenesis. Although stochastic decisions can be maintained to produce a mosaic of fates within a population of cells, they can also be compensated for or directed to yield robust and reproducible outcomes.
Robert J Johnston; Claude Desplan
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Review    
Journal Detail:
Title:  Annual review of cell and developmental biology     Volume:  26     ISSN:  1530-8995     ISO Abbreviation:  Annu. Rev. Cell Dev. Biol.     Publication Date:  2010  
Date Detail:
Created Date:  2010-10-08     Completed Date:  2010-10-26     Revised Date:  2014-09-15    
Medline Journal Info:
Nlm Unique ID:  9600627     Medline TA:  Annu Rev Cell Dev Biol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  689-719     Citation Subset:  IM    
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MeSH Terms
Bacteria / growth & development
Cell Differentiation
Cell Lineage*
Models, Biological*
Grant Support
R01 EY013010/EY/NEI NIH HHS; R01 EY013010/EY/NEI NIH HHS; R01 EY013010-13/EY/NEI NIH HHS

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