| Stimulus selectivity and spatial coherence of gamma components of the local field potential. | |
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MedLine Citation:
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PMID: 21697389 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The gamma frequencies of the local field potential (LFP) provide a physiological correlate for numerous perceptual and cognitive phenomena and have been proposed to play a role in cortical function. Understanding the spatial extent of gamma and its relationship to spiking activity is critical for interpreting this signal and elucidating its function, but previous studies have provided widely disparate views of these properties. We addressed these issues by simultaneously recording LFPs and spiking activity using microelectrode arrays implanted in the primary visual cortex of macaque monkeys. We find that the spatial extent of gamma and its relationship to local spiking activity is stimulus dependent. Small gratings, and those masked with noise, induce a broadband increase in spectral power. This signal is tuned similarly to spiking activity and has limited spatial coherence. Large gratings, however, induce a gamma rhythm characterized by a distinctive spectral "bump," which is coherent across widely separated sites. This signal is well tuned, but its stimulus preference is similar across millimeters of cortex. The preference of this global gamma rhythm is sensitive to adaptation, in a manner consistent with its magnifying a bias in the neuronal representation of visual stimuli. Gamma thus arises from two sources that reflect different spatial scales of neural ensemble activity. Our results show that there is not a single, fixed ensemble contributing to gamma and that the selectivity of gamma cannot be used to infer its spatial extent. |
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Authors:
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Xiaoxuan Jia; Matthew A Smith; Adam Kohn |
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Publication Detail:
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Type: Journal Article; Research Support, N.I.H., Extramural |
Journal Detail:
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Title: The Journal of neuroscience : the official journal of the Society for Neuroscience Volume: 31 ISSN: 1529-2401 ISO Abbreviation: J. Neurosci. Publication Date: 2011 Jun |
Date Detail:
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Created Date: 2011-06-23 Completed Date: 2011-09-02 Revised Date: 2011-12-23 |
Medline Journal Info:
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Nlm Unique ID: 8102140 Medline TA: J Neurosci Country: United States |
Other Details:
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Languages: eng Pagination: 9390-403 Citation Subset: IM |
Affiliation:
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Dominick Purpura Department of Neuroscience, Albert Einstein College of Medicine, Bronx, New York 10461, USA. jxiaoxuan@gmail.com |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Action Potentials
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physiology* Animals Biological Clocks / physiology* Brain Mapping / methods* Humans Macaca fascicularis Male Photic Stimulation / methods* Visual Cortex / physiology* |
| Grant Support | |
ID/Acronym/Agency:
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EY015958/EY/NEI NIH HHS; EY016774/EY/NEI NIH HHS; EY018894/EY/NEI NIH HHS; R01 EY016774-03/EY/NEI NIH HHS |
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