| Stimulus-response paradigm for characterizing the loss of resilience in homeostatic regulation associated with frailty. | |
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MedLine Citation:
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PMID: 18938195 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Frailty is a state of health signified by an increased vulnerability to adverse health outcomes in the face of stressors (e.g. infection). There is emerging consensus that research on both the theory and measurement of frailty must focus on the dynamic interactions within and across systems underlying the frailty syndrome. In this paper, we propose a dynamical systems modeling approach, based on the stimulus-response experimental paradigm, to propel future advances in the study of frailty. Our proposal is novel in that it provides a quantitative framework to operationalize and test the core notion underlying frailty that it signifies a loss of resilience in homeostatic regulation. The proposed framework offers many important benefits, including (a) insights into whether and how homeostatic regulation differs between frail and non-frail older adults, (b) identification of critical regulatory systems, if they exist, that could function as sentinel systems for screening and early detection of frailty, (c) establishment of the value of provocative tests that can provide maximal information on the integrity of systems identified in (b), and (d) evaluation and unification of diverse empirical descriptions of frailty by providing a mathematical framework anchored in quantifying the loss of resilience, an essential property of frailty. |
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Authors:
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R Varadhan; C L Seplaki; Q L Xue; K Bandeen-Roche; L P Fried |
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Publication Detail:
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Type: Journal Article; Research Support, N.I.H., Extramural Date: 2008-09-30 |
Journal Detail:
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Title: Mechanisms of ageing and development Volume: 129 ISSN: 0047-6374 ISO Abbreviation: Mech. Ageing Dev. Publication Date: 2008 Nov |
Date Detail:
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Created Date: 2008-12-08 Completed Date: 2009-03-05 Revised Date: 2013-06-05 |
Medline Journal Info:
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Nlm Unique ID: 0347227 Medline TA: Mech Ageing Dev Country: Ireland |
Other Details:
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Languages: eng Pagination: 666-70 Citation Subset: IM |
Affiliation:
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The Center on Aging and Health, Division of Geriatric Medicine and Gerontology, School of Medicine, Johns Hopkins University, Baltimore, MD 21205, United States. rvaradhan@jhmi.edu |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Aged Aged, 80 and over Aging / physiology* Biological Markers / metabolism Disease Susceptibility* Feedback, Physiological Frail Elderly* Homeostasis Humans Models, Biological* Phenotype Stress, Physiological* Systems Biology* Time Factors |
| Grant Support | |
ID/Acronym/Agency:
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P30 AG-021334-06/AG/NIA NIH HHS; P30 AG021334-06/AG/NIA NIH HHS; R37 AG019905-06/AG/NIA NIH HHS; R37 AG19905/AG/NIA NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/Biological Markers |
| Comments/Corrections | |
Comment In:
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Mech Ageing Dev. 2008 Nov;129(11):671-2
[PMID:
18952119
]
Mech Ageing Dev. 2008 Nov;129(11):677-9 [PMID: 18929593 ] Mech Ageing Dev. 2008 Nov;129(11):675-6 [PMID: 18930754 ] Mech Ageing Dev. 2008 Nov;129(11):673-4 [PMID: 18926846 ] Mech Ageing Dev. 2008 Nov;129(11):680 [PMID: 18929594 ] |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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