Document Detail


Stimulus-induced increase of taste responses in the hamster chorda tympani by repeated exposure to 'novel' tastants.
MedLine Citation:
PMID:  16112777     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Variations in amplitude of responses of the chorda tympani to repeated application of various novel tastants were measured in familiarized and control groups of adult hamsters. Three groups of 10 hamsters were pre-exposed to 5 mM dulcin, 50 mM potassium L-glutamate (KGlu) or 1 mM 5'guanosine monophosphate (5'GMP). In the fourth group, the tongue was rinsed with 5'GMP for 20 min just prior to recording from the chorda tympani. The tastants were novel to the fifth group (naïve control). A series of 17 stimuli was repeated six times and responses were quantified relative to the initial response of each of the 50 hamsters. The responses of the chorda tympani increased with repetition in the control group. In contrast, no increase in amplitude of response to the pre-exposed tastants or to stimuli with qualitatively related tastes was observed in the group familiarized with either KGlu or 5'GMP. These results indicate that the response of the chorda tympani depends on previous exposure to a tastant. The sensitivity of taste cells appears to be modulated, possibly by stimulus-induced supplementary receptors.
Authors:
M-V Berteretche; N Boireau-Ducept; A-M Pillias; A Faurion
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Publication Detail:
Type:  Comparative Study; Journal Article; Research Support, Non-U.S. Gov't     Date:  2005-08-19
Journal Detail:
Title:  Appetite     Volume:  45     ISSN:  0195-6663     ISO Abbreviation:  Appetite     Publication Date:  2005 Dec 
Date Detail:
Created Date:  2005-11-21     Completed Date:  2006-03-13     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  8006808     Medline TA:  Appetite     Country:  England    
Other Details:
Languages:  eng     Pagination:  324-33     Citation Subset:  IM    
Affiliation:
Laboratoire de Neurobiologie Sensorielle-NOPA, INRA-Domaine de Vilvert-Bat. 325, 78352 Jouy-en-Josas Cedex, France. berteretche.mv@wanadoo.fr
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MeSH Terms
Descriptor/Qualifier:
5'-Guanylic Acid / pharmacology
Animals
Chorda Tympani Nerve / drug effects*,  physiology*
Cricetinae
Evoked Potentials, Somatosensory / physiology*
Glutamates / pharmacology
Male
Phenylurea Compounds / pharmacology
Random Allocation
Taste / drug effects,  physiology*
Tongue / innervation,  physiology
Chemical
Reg. No./Substance:
0/Glutamates; 0/Phenylurea Compounds; 150-69-6/dulcin; 85-32-5/5'-Guanylic Acid

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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