| Stimulus-induced changes in blood flow and 2-deoxyglucose uptake dissociate in ipsilateral somatosensory cortex. | |
| | |
MedLine Citation:
|
PMID: 19118167 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
The present study addresses the relationship between blood flow and glucose consumption in rat primary somatosensory cortex (SI) in vivo. We examined bilateral neuronal and hemodynamic changes and 2-deoxyglucose (2DG) uptake, as measured by autoradiography, in response to unilateral forepaw stimulation. In contrast to the contralateral forepaw area, where neuronal activity, blood oxygenation/flow and 2DG uptake increased in unison, we observed, in the ipsilateral SI, a blood oxygenation/flow decrease and arteriolar vasoconstriction in the presence of increased 2DG uptake. Laminar electrophysiological recordings revealed an increase in ipsilateral spiking consistent with the observed increase in 2DG uptake. The vasoconstriction and the decrease in blood flow in the presence of an increase in 2DG uptake in the ipsilateral SI contradict the prominent metabolic hypothesis regarding the regulation of cerebral blood flow, which postulates that the state of neuroglial energy consumption determines the regional blood flow through the production of vasoactive metabolites. We propose that other factors, such as neuronal (and glial) release of messenger molecules, might play a dominant role in the regulation of blood flow in vivo in response to a physiological stimulus. |
| | |
Authors:
|
Anna Devor; Elizabeth M C Hillman; Peifang Tian; Christian Waeber; Ivan C Teng; Lana Ruvinskaya; Mark H Shalinsky; Haihao Zhu; Robert H Haslinger; Suresh N Narayanan; Istvan Ulbert; Andrew K Dunn; Eng H Lo; Bruce R Rosen; Anders M Dale; David Kleinfeld; David A Boas |
Related Documents
:
|
3979437 - The effect of graded doses of norepinephrine on the o2 supply/consumption balance in is... 9374647 - Oxygen sensitivity of mitochondrial metabolic state in isolated skeletal and cardiac my... 8599267 - Classes of tissue hypoxia. 16549907 - Effect of body warming on regional blood flow distribution in conscious hypoxic one-mon... 19259037 - Anticoagulation in combined membrane/adsorption systems. 6326417 - Unsuitability of blood culture media containing sodium polyanetholesulfonate for the de... |
Publication Detail:
|
Type: Journal Article; Research Support, N.I.H., Extramural |
Journal Detail:
|
Title: The Journal of neuroscience : the official journal of the Society for Neuroscience Volume: 28 ISSN: 1529-2401 ISO Abbreviation: J. Neurosci. Publication Date: 2008 Dec |
Date Detail:
|
Created Date: 2009-01-01 Completed Date: 2009-04-09 Revised Date: 2012-03-14 |
Medline Journal Info:
|
Nlm Unique ID: 8102140 Medline TA: J Neurosci Country: United States |
Other Details:
|
Languages: eng Pagination: 14347-57 Citation Subset: IM |
Affiliation:
|
Martinos Center for Biomedical Imaging, Stroke and Neurovascular Regulation Laboratory, Charlestown, Massachusetts 02129, USA. adevor@nmr.mgh.harvard.edu |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Animals Autoradiography / methods Brain Mapping Carbon Radioisotopes / metabolism Cerebrovascular Circulation / physiology* Deoxyglucose / metabolism* Evoked Potentials, Somatosensory / physiology* Functional Laterality / physiology* Hemodynamics Hemoglobins / metabolism Oxyhemoglobins / metabolism Rats Rats, Sprague-Dawley Somatosensory Cortex / blood supply, metabolism* Vasoconstriction / physiology |
| Grant Support | |
ID/Acronym/Agency:
|
EB003832/EB/NIBIB NIH HHS; EB00790/EB/NIBIB NIH HHS; EB2066/EB/NIBIB NIH HHS; NS-051188/NS/NINDS NIH HHS; NS-053684/NS/NINDS NIH HHS; NS-057476/NS/NINDS NIH HHS; NS-059832/NS/NINDS NIH HHS; NS-48422/NS/NINDS NIH HHS; P01NS-055104/NS/NINDS NIH HHS; R01 NS048422-04/NS/NINDS NIH HHS; R01 NS063226-05/NS/NINDS NIH HHS; R21 NS053684-01/NS/NINDS NIH HHS; R21 NS053684-02/NS/NINDS NIH HHS; R21 NS053684-03/NS/NINDS NIH HHS; RR021907/RR/NCRR NIH HHS |
| Chemical | |
Reg. No./Substance:
|
0/Carbon Radioisotopes; 0/Hemoglobins; 0/Oxyhemoglobins; 154-17-6/Deoxyglucose; 9008-02-0/deoxyhemoglobin |
| Comments/Corrections | |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: The bifunctional microRNA miR-9/miR-9* regulates REST and CoREST and is downregulated in Huntington'...
Next Document: Differential cAMP signaling at hippocampal output synapses.