Document Detail


Stimulus frequency and neuromuscular block.
MedLine Citation:
PMID:  13971398     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Muscle twitches of the rat isolated diaphragm and frog sartorius preparations were recorded. It was confirmed that, in the presence of tubocurarine, the degree of neuromuscular block was greater the higher the frequency of stimulation. The results suggest that the quantity of acetylcholine released by each nerve impulse was reduced by increasing the rate of stimulation so that, in a tubocurarine solution, muscle fibres which were only just being fired at a slow rate of stimulation failed to fire at a faster rate.
Authors:
J G BLACKMAN
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  British journal of pharmacology and chemotherapy     Volume:  20     ISSN:  0366-0826     ISO Abbreviation:  Br J Pharmacol Chemother     Publication Date:  1963 Feb 
Date Detail:
Created Date:  1963-12-01     Completed Date:  1998-11-01     Revised Date:  2009-11-18    
Medline Journal Info:
Nlm Unique ID:  0154627     Medline TA:  Br J Pharmacol Chemother     Country:  Not Available    
Other Details:
Languages:  eng     Pagination:  5-16     Citation Subset:  OM    
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MeSH Terms
Descriptor/Qualifier:
Acetylcholine*
Bis-Trimethylammonium Compounds*
Neuromuscular Junction*
Tetraethylammonium Compounds*
Tubocurarine*
Chemical
Reg. No./Substance:
0/Bis-Trimethylammonium Compounds; 0/Tetraethylammonium Compounds; 51-84-3/Acetylcholine; 57-95-4/Tubocurarine
Comments/Corrections

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