Document Detail


Stimulus features, resetting curves, and the dependence on adaptation.
MedLine Citation:
PMID:  23192247     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
We derive a formula that relates the spike-triggered covariance (STC) to the phase resetting curve (PRC) of a neural oscillator. We use this to show how changes in the shape of the PRC alter the sensitivity of the neuron to different stimulus features, which are the eigenvectors of the STC. We compute the PRC and STC for some biophysical models. We compare the STCs and their spectral properties for a two-parameter family of PRCs. Surprisingly, the skew of the PRC has a larger effect on the spectrum and shape of the STC than does the bimodality of the PRC (which plays a large role in synchronization properties). Finally, we relate the STC directly to the spike-triggered average and apply this theory to an olfactory bulb mitral cell recording.
Authors:
Joseph G Arthur; Shawn D Burton; G Bard Ermentrout
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Research Support, U.S. Gov't, Non-P.H.S.     Date:  2012-11-30
Journal Detail:
Title:  Journal of computational neuroscience     Volume:  34     ISSN:  1573-6873     ISO Abbreviation:  J Comput Neurosci     Publication Date:  2013 Jun 
Date Detail:
Created Date:  2013-05-10     Completed Date:  2013-12-09     Revised Date:  2014-08-24    
Medline Journal Info:
Nlm Unique ID:  9439510     Medline TA:  J Comput Neurosci     Country:  United States    
Other Details:
Languages:  eng     Pagination:  505-20     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Action Potentials / physiology*
Adaptation, Physiological / physiology*
Animals
Biophysics
Computer Simulation*
Models, Neurological*
Neurons / physiology*
Time Factors
Grant Support
ID/Acronym/Agency:
2T90DA022762-06/DA/NIDA NIH HHS; 5R01DC011184-06/DC/NIDCD NIH HHS; R01 DC011184/DC/NIDCD NIH HHS; T90 DA022762/DA/NIDA NIH HHS
Comments/Corrections

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