Document Detail


Stimulus competition by inhibitory interference.
MedLine Citation:
PMID:  16156934     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
When two stimuli are present in the receptive field of a V4 neuron, the firing rate response is between the weakest and strongest response elicited by each of the stimuli when presented alone (Reynolds, Chelazzi, & Desimone, 1999). When attention is directed toward the stimulus eliciting the strongest response (the preferred stimulus), the response to the pair is increased, whereas the response decreases when attention is directed to the other stimulus (the poor stimulus). When attention is directed to either of the two stimuli presented alone, the firing rate remains the same or increases slightly, but the coherence between the neuron's spike train and the local field potential can increase (Fries, Reynolds, Rorie, & Desimone, 2001). These experimental results were reproduced in a model of a V4 neuron under the assumption that attention modulates the activity of local interneuron networks. The V4 model neuron received stimulus-specific excitation from V2 and synchronous inhibitory inputs from two local interneuron networks in V4. Each interneuron network was driven by stimulus-specific excitatory inputs from V2 and was modulated by the activity of the frontal eye fields. Stimulus competition was present because of a delay in arrival time of synchronous volleys from each interneuron network. For small delays, the firing rate was close to the rate elicited by the preferred stimulus alone, whereas for larger delays, it approached the firing rate of the poor stimulus. When either stimulus was presented alone, the neuron's response was not altered by the change in delay, but could change due to modulation of the degree of synchrony of the corresponding interneuron network. The model suggests that top-down attention biases the competition between V2 columns for control of V4 neurons primarily by changing the relative timing of inhibition, whereas changes in the degree of synchrony of interneuron networks modulate the response to a single stimulus. The new mechanism proposed here for attentional modulation of firing rate, gain modulation by inhibitory interference, is likely to have more general applicability to cortical information processing.
Authors:
Paul H E Tiesinga
Related Documents :
11587894 - Neuroelectrical signs of selective attention to color in boys with attention-deficit hy...
22848844 - From abnormal hippocampal synaptic plasticity in down syndrome mouse models to cognitiv...
10762154 - Neural consequences of competing stimuli in both visual hemifields: a physiological bas...
19360654 - Self-other relations in social development and autism: multiple roles for mirror neuron...
24605774 - Cell types and coincident synapses in the ellipsoid body of drosophila.
8367474 - Response variability in retinal ganglion cells of primates.
Publication Detail:
Type:  Comparative Study; Journal Article    
Journal Detail:
Title:  Neural computation     Volume:  17     ISSN:  0899-7667     ISO Abbreviation:  Neural Comput     Publication Date:  2005 Nov 
Date Detail:
Created Date:  2005-09-13     Completed Date:  2005-11-21     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  9426182     Medline TA:  Neural Comput     Country:  United States    
Other Details:
Languages:  eng     Pagination:  2421-53     Citation Subset:  IM    
Affiliation:
Department of Physics and Astronomy, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA. tiesinga@physics.unc.edu
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:
Animals
Attention / physiology*
Humans
Models, Neurological*
Nerve Net / cytology,  physiology*
Neural Inhibition / physiology
Neurons / physiology*
Photic Stimulation / methods
Reaction Time / physiology
Synapses / physiology
Time Factors
Visual Cortex / cytology*
Visual Fields / physiology
Visual Pathways

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  How membrane properties shape the discharge of motoneurons: a detailed analytical study.
Next Document:  Optimization via intermittency with a self-organizing neural network.