Document Detail

Stimuli-responsive magnetic particles for biomedical applications.
MedLine Citation:
PMID:  20951779     Owner:  NLM     Status:  In-Data-Review    
In recent years, magnetic nanoparticles have been studied due to their potential applications as magnetic carriers in biomedical area. These materials have been increasingly exploited as efficient delivery vectors, leading to opportunities of use as magnetic resonance imaging (MRI) agents, mediators of hyperthermia cancer treatment and in targeted therapies. Much attention has been also focused on "smart" polymers, which are able to respond to environmental changes, such as changes in the temperature and pH. In this context, this article reviews the state-of-the art in stimuli-responsive magnetic systems for biomedical applications. The paper describes different types of stimuli-sensitive systems, mainly temperature- and pH sensitive polymers, the combination of this characteristic with magnetic properties and, finally, it gives an account of their preparation methods. The article also discusses the main in vivo biomedical applications of such materials. A survey of the recent literature on various stimuli-responsive magnetic gels in biomedical applications is also included.
S F Medeiros; A M Santos; H Fessi; A Elaissari
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Publication Detail:
Type:  Journal Article     Date:  2010-10-15
Journal Detail:
Title:  International journal of pharmaceutics     Volume:  403     ISSN:  1873-3476     ISO Abbreviation:  Int J Pharm     Publication Date:  2011 Jan 
Date Detail:
Created Date:  2010-12-14     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  7804127     Medline TA:  Int J Pharm     Country:  Netherlands    
Other Details:
Languages:  eng     Pagination:  139-61     Citation Subset:  IM    
Copyright Information:
Copyright © 2010 Elsevier B.V. All rights reserved.
LOM - Departamento de Engenharia de Materiais, Escola de Engenharia de Lorena-Universidade de São Paulo-USP, Caixa Postal 116, CEP 12602-810, Lorena, SP, Brazil; Université Lyon 1, CNRS, UMR 5007, Laboratoire d'Automatique et de Génie des Procédés, LAGEP-CPE-308G, 43 bd. du 11 Nov.1918, F-69622, Villeurbanne, France.
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