Document Detail

Stimuli-responsive LbL capsules and nanoshells for drug delivery.
MedLine Citation:
PMID:  21463658     Owner:  NLM     Status:  Publisher    
Review of basic principles and recent developments in the area of stimuli responsive polymeric capsules and nanoshells formed via layer-by-layer (LbL) is presented. The most essential attributes of the LbL approach are multifunctionality and responsiveness to a multitude of stimuli. The stimuli can be logically divided into three categories: physical (light, electric, magnetic, ultrasound, mechanical, temperature), chemical (pH, ionic strength, solvent, electrochemical) and biological (enzymes, receptors). Using these stimuli, numerous functionalities of nanoshells have been demonstrated: encapsulation, release including that inside living cells or in tissue, sensors, enzymatic reactions, enhancement of mechanical properties, fusion. This review describes mechanisms and basic principles of stimuli effects, describes progress in the area, and gives outlook for emerging trends and future directions.
Mihaela Delcea; Helmuth Möhwald; André G Skirtach
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2011-4-1
Journal Detail:
Title:  Advanced drug delivery reviews     Volume:  -     ISSN:  1872-8294     ISO Abbreviation:  -     Publication Date:  2011 Apr 
Date Detail:
Created Date:  2011-4-5     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8710523     Medline TA:  Adv Drug Deliv Rev     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Copyright Information:
Copyright © 2010. Published by Elsevier B.V.
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