Document Detail


Stimulatory effects of the flavanol (-)-epicatechin on cardiac angiogenesis: additive effects with exercise.
MedLine Citation:
PMID:  22833114     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The consumption of moderate amounts of cocoa products has been associated with reductions in the incidence of cardiovascular diseases. In animal studies, the flavanol (-)-epicatechin (Epi) yields cardioprotection. The effects may be partly due to its capacity to stimulate endothelial nitric oxide synthase (eNOS). The sustained activation of eNOS, as observed with exercise, can serve as a trigger of muscle angiogenesis via the activation of vascular endothelial growth factor (VEGF)-related events. Experiments were pursued to examine the potential of Epi to stimulate myocardial angiogenesis and determine the effects that its combined use with exercise (Ex) may trigger. Hearts obtained from a previous study were used for this purpose. Animals received 1 mg/kg of Epi or water (vehicle) via oral gavage (twice daily). Epi and/or Ex (by treadmill) was provided for 15 days. Results indicate that Ex or Epi significantly stimulate myocardial angiogenesis by ~30% above control levels. The use of Epi-Ex lead to further significant increases (to ~50%). Effects were associated with increases in protein levels and/or activation of canonical angiogenesis pathway associated events (HIF1a, VEGF, VEGFR2, PI3K, PDK, AKT, eNOS, NO, cGMP, MMP-2/-9, Src-1, and CD31). Thus, the use of Epi may represent a safe and novel means to stimulate myocardial angiogenesis.
Authors:
Israel Ramirez-Sanchez; Leonardo Nogueira; Aldo Moreno; Ann Murphy; Pam Taub; Guy Perkins; Guillermo M Ceballos; Michael Hogan; Moh Malek; Francisco Villarreal
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Journal of cardiovascular pharmacology     Volume:  60     ISSN:  1533-4023     ISO Abbreviation:  J. Cardiovasc. Pharmacol.     Publication Date:  2012 Nov 
Date Detail:
Created Date:  2012-11-12     Completed Date:  2013-04-11     Revised Date:  2013-11-06    
Medline Journal Info:
Nlm Unique ID:  7902492     Medline TA:  J Cardiovasc Pharmacol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  429-38     Citation Subset:  IM    
Affiliation:
Department of Medicine, University of California, San Diego, La Jolla, CA 92093, USA.
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MeSH Terms
Descriptor/Qualifier:
Administration, Oral
Angiogenesis Inducing Agents / blood,  pharmacology*
Animals
Blotting, Western
Capillaries / drug effects,  physiology
Cardiotonic Agents / blood,  pharmacology*
Catechin / blood,  pharmacology*
Coronary Vessels / drug effects,  physiology
Cyclic GMP / metabolism
Exercise Test
Male
Mice
Mice, Inbred C57BL
Myocardium / metabolism*
Neovascularization, Physiologic / drug effects*,  physiology
Nitric Oxide / metabolism
Physical Conditioning, Animal / physiology*
Grant Support
ID/Acronym/Agency:
AT4277/AT/NCCAM NIH HHS; HL43617/HL/NHLBI NIH HHS; P60-MD000220/MD/NIMHD NIH HHS; R01 HL043617/HL/NHLBI NIH HHS; R21 AT004277/AT/NCCAM NIH HHS; R24 DK092154/DK/NIDDK NIH HHS; RR004050/RR/NCRR NIH HHS
Chemical
Reg. No./Substance:
0/Angiogenesis Inducing Agents; 0/Cardiotonic Agents; 10102-43-9/Nitric Oxide; 154-23-4/Catechin; 7665-99-8/Cyclic GMP
Comments/Corrections

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