Document Detail


Stimulatory effect of intracerebroventricular administration of orexin A on food intake in the zebrafish, Danio rerio.
MedLine Citation:
PMID:  21616109     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
Orexin is a potent orexigenic neuropeptide implicated in feeding regulation of mammals. However, except for the case of goldfish, the involvement of orexin in the feeding behavior of teleost fish has not well been studied. Therefore, we investigated the role of orexin on food intake using a zebrafish (Danio rerio) model. We examined the effect of feeding status on orexin-like immunoreactivity and the expression level of orexin transcript in the brain. The number of neuronal cells showing orexin-like immunoreactivity in the hypothalamic region, including the posterior tuberal nucleus, was significantly increased in fish fasted for 7days. Orexin precursor mRNA levels in the brain obtained from fish fasted for 7days were higher than those in fish that had been fed normally. We then investigated the effect of intracerebroventricular (ICV) administration of orexin A on food intake. Cumulative food intake was significantly increased by ICV administration of orexin A (at 0.3 and 3pmol/g body weight, BW) during a 60-min observation period after treatment. The orexin A-induced orexigenic action (at 0.3pmol/g BW) was blocked by treatment with an orexin receptor antagonist, SB334867, at 10pmol/g BW. These results indicate that orexin A acts as feeding regulator in the zebrafish.
Authors:
Eri Yokobori; Kenji Kojima; Morio Azuma; Ki Sung Kang; Sho Maejima; Minoru Uchiyama; Kouhei Matsuda
Related Documents :
19968469 - Exploitation of food resources by the eurasian badger (meles meles) at the altitudinal ...
7119429 - A comparative assessment of efficacy of three anticoagulant rodenticides.
11927989 - Stability of species composition of fecal bifidobacteria in human subjects during ferme...
21451129 - Adult food intake patterns are related to adult and childhood socioeconomic status.
22170019 - Heat makes a difference in activity-based anorexia: a translational approach to treatme...
11714289 - Identification of hake species (merluccius genus) using sequencing and pcr-rflp analysi...
19038959 - Technical note: a method to quantify prolamin proteins in corn that are negatively rela...
7701059 - Pharmacological characterization of performance on a concurrent lever pressing/feeding ...
23433469 - Evaluating the effect of measurement error when using one or two 24 h dietary recalls ...
Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2011-5-14
Journal Detail:
Title:  Peptides     Volume:  -     ISSN:  1873-5169     ISO Abbreviation:  -     Publication Date:  2011 May 
Date Detail:
Created Date:  2011-5-27     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8008690     Medline TA:  Peptides     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Copyright Information:
Copyright © 2011. Published by Elsevier Inc.
Affiliation:
Laboratory of Regulatory Biology, Graduate School of Science and Engineering, University of Toyama, 3190-Gofuku, Toyama, Toyama 930-8555, Japan.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  Viral delivery for gene therapy against cell movement in cancer.
Next Document:  Effects of cell-type specific leptin receptor mutation on leptin transport across the BBB.