Document Detail

Stimulatory effect of histamine on normal human melanocytes in vitro.
MedLine Citation:
PMID:  3145628     Owner:  NLM     Status:  MEDLINE    
Normal human epidermal melanocytes became swollen and more dendritic and the immunoreactive tyrosinase increased markedly when they were cultured for 2 days with 5 microM of histamine. These results suggest that high dermal concentrations of histamine may be responsible for the induction of skin pigmentary changes associated with local proliferation of mast cells such as in urticaria pigmentosa and systemic mastocytosis.
Y Tomita; K Maeda; H Tagami
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  The Tohoku journal of experimental medicine     Volume:  155     ISSN:  0040-8727     ISO Abbreviation:  Tohoku J. Exp. Med.     Publication Date:  1988 Jun 
Date Detail:
Created Date:  1989-02-23     Completed Date:  1989-02-23     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0417355     Medline TA:  Tohoku J Exp Med     Country:  JAPAN    
Other Details:
Languages:  eng     Pagination:  209-10     Citation Subset:  IM    
Department of Dermatology, Tohoku University School of Medicine, Sendai.
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MeSH Terms
Cells, Cultured
Histamine / pharmacology*
Melanocytes / cytology,  drug effects,  physiology*
Monophenol Monooxygenase / metabolism
Reference Values
Reg. No./Substance:
51-45-6/Histamine; EC Monooxygenase

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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