| Stimulatory effect of clofibrate on the action of estradiol in the mammary gland but not in the uterus of rats. | |
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MedLine Citation:
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PMID: 11259527 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Treatment of ovariectomized rats with dietary clofibrate caused a manyfold increase in the liver microsomal esterification of estradiol with fatty acids. The stimulatory effect of clofibrate administration on fatty acid esterification of estradiol by liver microsomes was paralleled in vivo by enhanced estradiol-induced increases in the formation of lobules in the mammary gland and by increased incorporation of bromodeoxyuridine into these lobules. In contrast to the stimulatory effect of clofibrate administration on the action of estradiol in the mammary gland, clofibrate administration had no effect on the uterotropic action of estradiol. These results indicate that clofibrate administration has a selective stimulatory effect on the hormonal action of estradiol in the mammary gland but not in the uterus. |
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Authors:
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S Xu; B T Zhu; M X Cai; A H Conney |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: The Journal of pharmacology and experimental therapeutics Volume: 297 ISSN: 0022-3565 ISO Abbreviation: J. Pharmacol. Exp. Ther. Publication Date: 2001 Apr |
Date Detail:
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Created Date: 2001-03-22 Completed Date: 2001-05-03 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 0376362 Medline TA: J Pharmacol Exp Ther Country: United States |
Other Details:
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Languages: eng Pagination: 50-6 Citation Subset: IM |
Affiliation:
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Laboratory for Cancer Research, Department of Chemical Biology, College of Pharmacy, Rutgers, The State University of New Jersey, 164 Frelinghuysen Rd., Piscataway, NJ 08854-8020, USA. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Acyl Coenzyme A
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metabolism Animals Antilipemic Agents / pharmacology* Clofibrate / pharmacology* Dose-Response Relationship, Drug Estradiol / metabolism, pharmacology* Female Mammary Glands, Animal / drug effects*, pathology Microsomes, Liver / metabolism Ovariectomy Rats Rats, Sprague-Dawley Uterus / drug effects*, pathology |
| Chemical | |
Reg. No./Substance:
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0/Acyl Coenzyme A; 0/Antilipemic Agents; 50-28-2/Estradiol; 637-07-0/Clofibrate |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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