Document Detail


Stimulatory effect of clofibrate on the action of estradiol in the mammary gland but not in the uterus of rats.
MedLine Citation:
PMID:  11259527     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Treatment of ovariectomized rats with dietary clofibrate caused a manyfold increase in the liver microsomal esterification of estradiol with fatty acids. The stimulatory effect of clofibrate administration on fatty acid esterification of estradiol by liver microsomes was paralleled in vivo by enhanced estradiol-induced increases in the formation of lobules in the mammary gland and by increased incorporation of bromodeoxyuridine into these lobules. In contrast to the stimulatory effect of clofibrate administration on the action of estradiol in the mammary gland, clofibrate administration had no effect on the uterotropic action of estradiol. These results indicate that clofibrate administration has a selective stimulatory effect on the hormonal action of estradiol in the mammary gland but not in the uterus.
Authors:
S Xu; B T Zhu; M X Cai; A H Conney
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  The Journal of pharmacology and experimental therapeutics     Volume:  297     ISSN:  0022-3565     ISO Abbreviation:  J. Pharmacol. Exp. Ther.     Publication Date:  2001 Apr 
Date Detail:
Created Date:  2001-03-22     Completed Date:  2001-05-03     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0376362     Medline TA:  J Pharmacol Exp Ther     Country:  United States    
Other Details:
Languages:  eng     Pagination:  50-6     Citation Subset:  IM    
Affiliation:
Laboratory for Cancer Research, Department of Chemical Biology, College of Pharmacy, Rutgers, The State University of New Jersey, 164 Frelinghuysen Rd., Piscataway, NJ 08854-8020, USA.
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MeSH Terms
Descriptor/Qualifier:
Acyl Coenzyme A / metabolism
Animals
Antilipemic Agents / pharmacology*
Clofibrate / pharmacology*
Dose-Response Relationship, Drug
Estradiol / metabolism,  pharmacology*
Female
Mammary Glands, Animal / drug effects*,  pathology
Microsomes, Liver / metabolism
Ovariectomy
Rats
Rats, Sprague-Dawley
Uterus / drug effects*,  pathology
Chemical
Reg. No./Substance:
0/Acyl Coenzyme A; 0/Antilipemic Agents; 50-28-2/Estradiol; 637-07-0/Clofibrate

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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