| Stimulatory effect of apigenin-6-C-beta-L-fucopyranoside on insulin secretion and glycogen synthesis. | |
| | |
MedLine Citation:
|
PMID: 19625113 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
In vivo and in vitro treatments were carried out to investigate the effects of apigenin-6-C-beta-L-fucopyranoside (1), isolated from Averrhoa carambola L. (Oxalidaceae), on serum glucose and insulin levels in hyperglycemic rats as well as its effect on glycogen synthesis in normal rat soleus muscle. Apigenin-6-C-beta-L-fucopyranoside showed an acute effect on blood glucose lowering in hyperglycemic rats and stimulated glucose-induced insulin secretion. A stimulatory effect of 1 on glycogen synthesis was observed when muscles were incubated with this flavonoid and also its effect was completely nullified by pre-treatment with insulin signal transduction inhibitors. Taking this into account, the MAPK-PP1 and PI3K-GSK3 pathways are involved in the apigenin-6-C-beta-L-fucopyranoside-induced increase in glycogen synthesis in muscle. This study provides evidence for dual effects of apigenin-6-C-beta-L-fucopyranoside as an antihyperglycemic (insulin secretion) as well as an insulinomimetic (glycogen synthesis) agent. |
| | |
Authors:
|
Luisa Helena Cazarolli; Poliane Folador; Henrique Hunger Moresco; In??s Maria Costa Brighente; Moacir Geraldo Pizzolatti; F??tima Regina M Barreto Silva |
Related Documents
:
|
2505753 - Insulin controls key steps of carbohydrate metabolism in cultured ht29 colon cancer cells. 12711303 - Axin and the axin/arrow-binding protein dcap mediate glucose-glycogen metabolism. 6225473 - Sorbsan calcium alginate fibre dressings in footcare. |
Publication Detail:
|
Type: Journal Article; Research Support, Non-U.S. Gov't Date: 2009-07-09 |
Journal Detail:
|
Title: European journal of medicinal chemistry Volume: 44 ISSN: 1768-3254 ISO Abbreviation: Eur J Med Chem Publication Date: 2009 Nov |
Date Detail:
|
Created Date: 2009-10-09 Completed Date: 2010-01-28 Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 0420510 Medline TA: Eur J Med Chem Country: France |
Other Details:
|
Languages: eng Pagination: 4668-73 Citation Subset: IM |
Affiliation:
|
Departamento de Bioqu??mica, Centro de Ci??ncias Biol??gicas, Universidade Federal de Santa Catarina, Campus Universit??rio, Bairro Trindade, Florian??polis, SC, Brazil. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Animals Apigenin / isolation & purification, therapeutic use* Ferns / chemistry* Glycogen / metabolism* Glycosides / isolation & purification, therapeutic use* Hypoglycemic Agents / isolation & purification, therapeutic use* Insulin / metabolism* Male Muscle, Skeletal / drug effects Plant Extracts / isolation & purification, therapeutic use* Plant Leaves / chemistry Rats Rats, Wistar |
| Chemical | |
Reg. No./Substance:
|
0/Glycosides; 0/Hypoglycemic Agents; 0/Plant Extracts; 0/apigenin-6-C-beta-L-fucopyranoside; 11061-68-0/Insulin; 520-36-5/Apigenin; 9005-79-2/Glycogen |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Macrolides and ketolides.
Next Document: Towards a coherent conceptual framework for emergency preparedness/response and rehabilitation - the...