| Stimulation of release of adrenal catecholamine by adenosine 3':5'-cyclic monophosphate and theophylline in the absence of extracellular Ca 2+ . | |
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MedLine Citation:
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PMID: 4337240 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Stimulation of catecholamine release was studied in the isolated adrenal of the cat during retrograde perfusion. Theophylline, adenosine 3':5'-cyclic monophosphate (cyclic AMP), and dibutyryl-cyclic AMP stimulated catecholamine release in adrenal chromaffin tissue; adenosine, 2'-AMP, 3'-AMP, and 5'-AMP were ineffective. Addition of theophylline for 5-15 min had no effect on catecholamine release induced by KCl or nicotine, but it significantly increased the responses to cyclic AMP and its dibutyryl derivative. Glands perfused with Ca(2+)-free Locke's solution for 30-180 min rapidly lost their responsiveness to KCl or nicotine. In contrast, exposure to Ca(2+)-free medium for 180 min had no effect on secretory responses to either the cyclic nucleotides, themselves, or to methylxanthine-induced potentiation of cyclic AMP responses. Thus, dibutyryl-cyclic AMP, cyclic AMP, and theophylline do not require extracellular Ca(2+) to release adrenal catecholamines. They may act by translocating intracellular bound Ca(2+) or by a mechanism independent of calcium. |
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Authors:
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M J Peach |
Publication Detail:
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Type: In Vitro; Journal Article |
Journal Detail:
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Title: Proceedings of the National Academy of Sciences of the United States of America Volume: 69 ISSN: 0027-8424 ISO Abbreviation: Proc. Natl. Acad. Sci. U.S.A. Publication Date: 1972 Apr |
Date Detail:
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Created Date: 1972-07-20 Completed Date: 1972-07-20 Revised Date: 2009-11-18 |
Medline Journal Info:
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Nlm Unique ID: 7505876 Medline TA: Proc Natl Acad Sci U S A Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 834-6 Citation Subset: IM |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adenosine
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pharmacology Adenosine Monophosphate / pharmacology Adrenal Glands / drug effects, secretion* Animals Butyrates / pharmacology Calcium / pharmacology* Catecholamines / secretion* Cats Cyclic AMP / pharmacology* Drug Synergism Female Male Nicotine / pharmacology Perfusion Potassium Chloride / pharmacology Stimulation, Chemical Theophylline / pharmacology* Time Factors Xanthines / pharmacology |
| Chemical | |
Reg. No./Substance:
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0/Butyrates; 0/Catecholamines; 0/Xanthines; 54-11-5/Nicotine; 58-55-9/Theophylline; 58-61-7/Adenosine; 60-92-4/Cyclic AMP; 61-19-8/Adenosine Monophosphate; 7440-70-2/Calcium; 7447-40-7/Potassium Chloride |
| Comments/Corrections | |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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