Document Detail

Stimulation region within the globus pallidus does not affect verbal fluency performance.
MedLine Citation:
PMID:  22766102     Owner:  NLM     Status:  MEDLINE    
BACKGROUND: Subthalamic (STN) and globus pallidus (GP) deep brain stimulation (DBS) have been previously shown to be efficacious in the treatment of selected Parkinson patients with medication resistant motor fluctuations and/or tremor. Deep brain stimulation of the STN has been implicated with more cognitive and mood side effects as compared to GP DBS; however, more studies are needed to better understand possible target differences. Previously, Mikos et al. [1] reported worsening of verbal fluency depending on the stimulation location within the STN region.
OBJECTIVE/HYPOTHESIS: The current study applied the methods used by Mikos et al. (2011) to a different sample of Parkinson patients who underwent GP DBS. Based on differences in the size and functional somatotopy between structures (GP 412 mm(3) vs. STN 167 mm(3)), we hypothesized that there would be a less robust relationship between volume of tissue activated, fluency performance, and stimulation contact within the GP compared to what was reported in the STN.
METHODS: Patient-specific DBS models were created and the volume of tissue activated within the GP was calculated. These data were correlated with patients' verbal fluency performance at dorsal, optimal, and ventral stimulation contacts.
RESULTS: In contrast to STN findings, there was no significant relationship between stimulation location and fluency performance in patients who received GP DBS.
CONCLUSION(S): These results suggest that fluency may be less sensitive to stimulation location in the globus pallidus and thus there may be more flexibility in terms of DBS programming with GP DBS patients.
Jenna Dietz; Angela M Noecker; Cameron C McIntyre; Ania Mikos; Dawn Bowers; Kelly D Foote; Michael S Okun
Publication Detail:
Type:  Journal Article; Randomized Controlled Trial; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't     Date:  2012-06-16
Journal Detail:
Title:  Brain stimulation     Volume:  6     ISSN:  1935-861X     ISO Abbreviation:  Brain Stimul     Publication Date:  2013 May 
Date Detail:
Created Date:  2013-05-13     Completed Date:  2013-12-11     Revised Date:  2014-05-09    
Medline Journal Info:
Nlm Unique ID:  101465726     Medline TA:  Brain Stimul     Country:  United States    
Other Details:
Languages:  eng     Pagination:  248-53     Citation Subset:  IM    
Copyright Information:
Copyright © 2013 Elsevier Inc. All rights reserved.
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MeSH Terms
Deep Brain Stimulation / methods*
Globus Pallidus / physiology*
Magnetic Resonance Imaging
Middle Aged
Parkinson Disease / complications,  therapy*
Speech Disorders / etiology,  therapy*
Statistics, Nonparametric
Ventral Tegmental Area / physiology
Verbal Behavior / physiology*
Grant Support

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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