Document Detail

Stimulation regimens in Assisted Reproductive Technology (ART) programme: experience in the University Hospital, Singapore.
MedLine Citation:
PMID:  8373118     Owner:  NLM     Status:  MEDLINE    
Ovarian stimulation is critical to the success of patients in Assisted Reproductive Technology (ART) programmes. We compared two stimulation regimes retrospectively for ART in the NUH programme. These were the 2:1 and the GnRHa-FSH/hMG regimes. The former was our first-line regime while the latter was used for cycles where there was a prior endogenous LH surge, previous poor response, or an elevated LH level between days three to five of the cycle. All cycles in our ART programme in 1991 were studied, except those for special research procedures, e.g. micro-insemination sperm transfer (MIST) cycles, a total of 241 cycles. Cancellation rates were 14.4% (21 of 146 cycles) and 37.3% (19 of 51 cycles) for the 2:1 and GnRHa-FSH/hMG regimes respectively (p > 0.001). For the 2:1 regime, the majority of cancellations were due to ovulation prior to the oocyte recovery (42.9%; nine of 21 cycles). However, for the GnRHa-FSH/hMG regime, almost all the cancellations were due to poor response (84.2%; 16 of 19 cycles). Fertilisation rates were lower for the 2:1 regime (for both IVF-ER and IVF-TET, where sperm quality was poorer) compared to the GnRHa-FSH/hMG (55.0 and 66.6% respectively; p < 0.001). Pregnancy rates were higher for the 2:1 regime when IVF-ER and IVF-TET were used (16.4% and 23.3% respectively per oocyte recovery, versus 9.8% and 18.8% respectively for the GnRHa-FSH/hMG regime).
S S Ratnam; S Devendra; B Marshall; C Anandkumar; Y C Wong; H H Goh; T A Bongso; C L Chan; J Kumar; S C Ng
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Publication Detail:
Type:  Comparative Study; Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Annals of the Academy of Medicine, Singapore     Volume:  22     ISSN:  0304-4602     ISO Abbreviation:  Ann. Acad. Med. Singap.     Publication Date:  1993 May 
Date Detail:
Created Date:  1993-10-08     Completed Date:  1993-10-08     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  7503289     Medline TA:  Ann Acad Med Singapore     Country:  SINGAPORE    
Other Details:
Languages:  eng     Pagination:  351-4     Citation Subset:  IM    
Department of Obstetrics & Gynecology, National University Hospital, Singapore.
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MeSH Terms
Drug Evaluation
Fertilization / drug effects
Follicle Stimulating Hormone / pharmacology
Gonadotropin-Releasing Hormone / analogs & derivatives,  pharmacology
Hospitals, University*
Menotropins / pharmacology
Menstrual Cycle / drug effects
Pregnancy / statistics & numerical data
Reproductive Techniques*
Stimulation, Chemical
Reg. No./Substance:
33515-09-2/Gonadotropin-Releasing Hormone; 61489-71-2/Menotropins; 9002-68-0/Follicle Stimulating Hormone

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