| Stimulation of prostaglandin production in rat thymic epithelial cells by protein kinase C mediated activation of phospholipase A2. | |
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MedLine Citation:
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PMID: 1417924 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Tumor promoter (phorbol-12-myristate-13-acetate:PMA) stimulates the production of prostaglandin E2 (PGE2) in a dose- and time-dependent manner in cloned rat thymic epithelial cells, TEA3A1. This stimulation of PGE2 production by PMA was blocked by pretreatment of cells with protein kinase C (PKC) inhibitor staurosporin and was abolished in PKC down modulated cells. PMA treatment significantly stimulated the release of arachidonic acid from the cells, but had no effect on arachidonic acid incorporation and on cyclooxygenase enzymatic activity of the cells. These results indicate that PMA stimulates PGE2 production through PKC mediated activation of phospholipase A2 (PLA2) in thymic epithelial cells. |
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Authors:
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P S Liu; L Sun; M Wen; J Hayashi |
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Publication Detail:
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Type: Journal Article; Research Support, U.S. Gov't, P.H.S. |
Journal Detail:
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Title: Biochemistry international Volume: 27 ISSN: 0158-5231 ISO Abbreviation: Biochem. Int. Publication Date: 1992 Aug |
Date Detail:
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Created Date: 1992-11-23 Completed Date: 1992-11-23 Revised Date: 2007-11-15 |
Medline Journal Info:
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Nlm Unique ID: 8100311 Medline TA: Biochem Int Country: AUSTRALIA |
Other Details:
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Languages: eng Pagination: 931-8 Citation Subset: IM |
Affiliation:
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W. Alton Jones Cell Science Center, Lake Placid, NY 12946. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Arachidonic Acid / metabolism* Cells, Cultured Dinoprostone / biosynthesis* Enzyme Activation / physiology Epithelium / metabolism Phospholipases A / drug effects, metabolism* Phospholipases A2 Protein Kinase C / physiology* Rats Tetradecanoylphorbol Acetate / pharmacology* Thymus Gland / metabolism* |
| Grant Support | |
ID/Acronym/Agency:
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DK38639/DK/NIDDK NIH HHS |
| Chemical | |
Reg. No./Substance:
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16561-29-8/Tetradecanoylphorbol Acetate; 363-24-6/Dinoprostone; 506-32-1/Arachidonic Acid; EC 2.7.11.13/Protein Kinase C; EC 3.1.1.-/Phospholipases A; EC 3.1.1.4/Phospholipases A2 |
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