Document Detail

Stimulation of prostaglandin E2 synthesis in human amnion cells maintained in monolayer culture by a substance(s) in amniotic fluid.
MedLine Citation:
PMID:  6593749     Owner:  NLM     Status:  MEDLINE    
A substance(s) in amniotic fluid of human pregnancies promotes a striking increase in prostaglandin E2 production in human amnion cells maintained in primary monolayer culture. The prostaglandin E2 synthesis-stimulatory factor(s) acts in a time- and dose-dependent manner to accelerate prostaglandin E2 formation. We suggest that a substance of fetal origin enters amniotic fluid by way of fetal urine and acts to regulate prostaglandin E2 synthesis in amnion. Such a process may be of fundamental importance in the regulation of amniotic fluid volume homeostasis and in the initiation of parturition.
M D Mitchell; P C MacDonald; M L Casey
Related Documents :
6683079 - Relationship between amniotic fluid volume and maternal plasma volume expansion.
6593749 - Stimulation of prostaglandin e2 synthesis in human amnion cells maintained in monolayer...
16697939 - Chronic exposure to intra-amniotic lipopolysaccharide affects the ovine fetal brain.
6478059 - Factor ix and prothrombin in amniotic fluid and fetal plasma: constraints on prenatal d...
8177829 - Abnormal amniotic fluid levels of ca 125 in second-trimester down syndrome pregnancies.
8403459 - Prenatal diagnosis of congenital sialidosis.
24642719 - Impact of a low glycemic index diet in pregnancy on markers of maternal and fetal metab...
2984059 - Involvement of the regulatory protein (ns) in the maturation of acth-sensitive adenylat...
12797269 - Single umbilical artery: a doppler flow velocity study of four cases.
Publication Detail:
Type:  Comparative Study; Journal Article; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Prostaglandins, leukotrienes, and medicine     Volume:  15     ISSN:  0262-1746     ISO Abbreviation:  Prostaglandins Leukot Med     Publication Date:  1984 Sep 
Date Detail:
Created Date:  1984-12-05     Completed Date:  1984-12-05     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  8206868     Medline TA:  Prostaglandins Leukot Med     Country:  SCOTLAND    
Other Details:
Languages:  eng     Pagination:  399-407     Citation Subset:  IM    
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Amnion / metabolism*
Amniotic Fluid / metabolism*
Cells, Cultured
Fetus / metabolism
Labor, Obstetric
Prostaglandins E / biosynthesis*
Grant Support
Reg. No./Substance:
0/Prostaglandins E; 363-24-6/Dinoprostone

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  The effect of prostaglandin D2 (PGD2) on circulating eosinophils.
Next Document:  Naloxone alters the effects of LSD, DOM and quipazine on operant behavior of rats.