Document Detail


Stimulation of prostaglandin E2 synthesis in human amnion cells maintained in monolayer culture by a substance(s) in amniotic fluid.
MedLine Citation:
PMID:  6593749     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
A substance(s) in amniotic fluid of human pregnancies promotes a striking increase in prostaglandin E2 production in human amnion cells maintained in primary monolayer culture. The prostaglandin E2 synthesis-stimulatory factor(s) acts in a time- and dose-dependent manner to accelerate prostaglandin E2 formation. We suggest that a substance of fetal origin enters amniotic fluid by way of fetal urine and acts to regulate prostaglandin E2 synthesis in amnion. Such a process may be of fundamental importance in the regulation of amniotic fluid volume homeostasis and in the initiation of parturition.
Authors:
M D Mitchell; P C MacDonald; M L Casey
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Publication Detail:
Type:  Comparative Study; Journal Article; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Prostaglandins, leukotrienes, and medicine     Volume:  15     ISSN:  0262-1746     ISO Abbreviation:  Prostaglandins Leukot Med     Publication Date:  1984 Sep 
Date Detail:
Created Date:  1984-12-05     Completed Date:  1984-12-05     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  8206868     Medline TA:  Prostaglandins Leukot Med     Country:  SCOTLAND    
Other Details:
Languages:  eng     Pagination:  399-407     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Amnion / metabolism*
Amniotic Fluid / metabolism*
Cells, Cultured
Dinoprostone
Female
Fetus / metabolism
Humans
Labor, Obstetric
Pregnancy
Prostaglandins E / biosynthesis*
Grant Support
ID/Acronym/Agency:
5-P50-HD11149/HD/NICHD NIH HHS
Chemical
Reg. No./Substance:
0/Prostaglandins E; 363-24-6/Dinoprostone

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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