Document Detail

Stimulation of progesterone production by adrenocorticotropic hormone and prostaglandin E2 in rat luteal cells.
MedLine Citation:
PMID:  3017465     Owner:  NLM     Status:  MEDLINE    
The effects of adrenocorticotropic hormone (ACTH), human chorionic gonadotropin (hCG) and prostaglandin E2 (PGE2) on the progesterone secretion of luteal cells from rats were studied. Corpora lutea were harvested on Day 6 of pseudopregnancy and digested by trypsin. Homogeneous suspensions of luteal cells were used for short-term incubation. ACTH, PGE2, and hCG were added to the medium and the changes in progesterone production were measured by radioimmunoassay (RIA). Furthermore, specific ACTH-binding sites of the luteal cell membrane were studied by Scatchard analysis. ACTH, PGE2 and hCG increased synthesis of progesterone, and the combination of hCG with ACTH or PGE2 further increased production of the hormone. The effect of ACTH could be prevented by indomethacin. These effect of ACTH seem to be connected with specific ACTH-binding sites of the luteal cell membrane and with increased production of PGE2.
E Horváth; B Varga; E Stark
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Biology of reproduction     Volume:  35     ISSN:  0006-3363     ISO Abbreviation:  Biol. Reprod.     Publication Date:  1986 Aug 
Date Detail:
Created Date:  1986-10-20     Completed Date:  1986-10-20     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0207224     Medline TA:  Biol Reprod     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  44-8     Citation Subset:  IM    
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MeSH Terms
Adrenocorticotropic Hormone / metabolism,  pharmacology*
Corpus Luteum / drug effects,  metabolism*
Progesterone / biosynthesis*
Prostaglandins E / pharmacology*
Rats, Inbred Strains
Receptors, Cell Surface / metabolism
Receptors, Corticotropin
Reg. No./Substance:
0/Prostaglandins E; 0/Receptors, Cell Surface; 0/Receptors, Corticotropin; 57-83-0/Progesterone; 9002-60-2/Adrenocorticotropic Hormone

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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