| Stimulation of the pituitary-adrenal system with graded doses of CRH and low dose vasopressin infusion in depressed patients and healthy subjects: a pilot study. | |
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MedLine Citation:
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PMID: 8111227 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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A corticotropin-releasing hormone (CRH) stimulation test with four cumulative doses of human CRH (0.01, 0.06, 0.2 and 1 microgram/kg body weight) and infusion of a low dose of [Arg8]-vasopressin (0.004 U/kg body weight/30 min) was performed in five depressed patients and six healthy subjects. Plasma samples for the measurement of cortisol, ACTH and beta-endorphin were taken at regular intervals and considered as measures of pituitary-adrenal function. A dose-response relationship between CRH and the hormones measured was found in patients and controls. Depressed patients already responded to the lowest dose of CRH with respect to cortisol release, whereas ACTH and beta-endorphin responded to the second and third doses, respectively. In control subjects the cortisol and ACTH response started after the third dose of CRH, whereas beta-endorphin responded significantly to the highest dose only. When both groups were compared, differences in response were found to the higher doses of CRH with respect to cortisol, ACTH and, less markedly, beta-endorphin and to the lowest dose of CRH with respect to cortisol. Although numbers are small, the data show 'blunting' of the ACTH response to the higher doses of CRH in patients with an enhanced cortisol response of the adrenals to lower and higher doses of CRH. There was no significant difference in response when CRH was used with vasopressin as compared to treatment with CRH alone. Thus, in this design vasopressin did not contribute significantly to CRH activity. The data suggest that pituitary cell sensitivity might be changed in depression as part of HPA dysfunction. |
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Authors:
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C C Gispen-de Wied; F W Kok; H P Koppeschaar; H J Wynne; H G Westenberg; J H Thijssen; J M van Ree |
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Publication Detail:
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Type: Comparative Study; Journal Article |
Journal Detail:
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Title: European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology Volume: 3 ISSN: 0924-977X ISO Abbreviation: Eur Neuropsychopharmacol Publication Date: 1993 Dec |
Date Detail:
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Created Date: 1994-03-31 Completed Date: 1994-03-31 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 9111390 Medline TA: Eur Neuropsychopharmacol Country: NETHERLANDS |
Other Details:
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Languages: eng Pagination: 533-41 Citation Subset: IM |
Affiliation:
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Department of Psychiatry, Academic Hospital, Utrecht, The Netherlands. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adrenocorticotropic Hormone
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blood Adult Arginine Vasopressin / administration & dosage, pharmacology* Corticotropin-Releasing Hormone / pharmacology* Depressive Disorder / metabolism*, psychology Dose-Response Relationship, Drug Female Humans Hydrocortisone / blood Infusions, Intravenous Male Middle Aged Pilot Projects Pituitary-Adrenal System / drug effects* Psychiatric Status Rating Scales Stimulation, Chemical beta-Endorphin / blood |
| Chemical | |
Reg. No./Substance:
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113-79-1/Arginine Vasopressin; 50-23-7/Hydrocortisone; 60617-12-1/beta-Endorphin; 9002-60-2/Adrenocorticotropic Hormone; 9015-71-8/Corticotropin-Releasing Hormone |
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