Document Detail

Stimulation of metabotropic glutamate receptors in the dorsomedial hypothalamus elevates heart rate in rats.
MedLine Citation:
PMID:  8928914     Owner:  NLM     Status:  MEDLINE    
This study examined the potential role of metabotropic glutamate receptors (mGluRs) in the dorsomedial hypothalamus (DMH) by assessing the cardiovascular effects of microinjecting the agonist trans-1-aminocyclopentane-1, 3- dicarboxylate (tACPD) into this region in urethan-anesthetized rats. Dose-related tachycardia was observed after unilateral microinjection of 1S 3R-tACPD (10-200 pmol/50nl) but not after injection of 1R, 3S-tACPD, which has been reported to have little or no activity at mGluRs. Microinjection of dihydroxyphenylglycine, an agonist at mGluRs linked to phosphoinositide hydrolysis, resulted in increases in heart rate that correlated closely in magnitude to those seen after injection of the same dose of 1S, 3R-tACPD. Coinjection of the N-methyl-D-aspartate (NMDA) receptor antagonist DL-2- amino-5-phosphonopentanoic acid, given at doses shown to elicit selective blockade of NMDA ionotropic glutamate receptors, reduced the increase in heart rate evoked by 100 pmol 1S, 3R-tACPD alone. Thus the DMH contains functional mGluRs, and stimulation of these receptors activates the same sympathoexcitatory mechanism characterized previously to provoke dose-related tachycardia.
J DiMicco; A J Monroe
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Publication Detail:
Type:  Journal Article; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  The American journal of physiology     Volume:  270     ISSN:  0002-9513     ISO Abbreviation:  Am. J. Physiol.     Publication Date:  1996 May 
Date Detail:
Created Date:  1996-11-27     Completed Date:  1996-11-27     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  0370511     Medline TA:  Am J Physiol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  R1115-21     Citation Subset:  IM    
Department of Pharmacology and Toxicology, Indiana University School of Medicine, Indianapolis, 46202-5120, USA.
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MeSH Terms
2-Amino-5-phosphonovalerate / pharmacology
Cycloleucine / analogs & derivatives,  pharmacology
Dose-Response Relationship, Drug
Glycine / analogs & derivatives,  pharmacology
Heart Rate / drug effects,  physiology*
Hypothalamus, Middle / metabolism*
Rats, Sprague-Dawley
Receptors, Metabotropic Glutamate / physiology*
Receptors, N-Methyl-D-Aspartate / antagonists & inhibitors
Resorcinols / pharmacology
Tachycardia / chemically induced
Grant Support
Reg. No./Substance:
0/Receptors, Metabotropic Glutamate; 0/Receptors, N-Methyl-D-Aspartate; 0/Resorcinols; 111900-32-4/1-amino-1,3-dicarboxycyclopentane; 146255-66-5/3,5-dihydroxyphenylglycine; 52-52-8/Cycloleucine; 56-40-6/Glycine; 76726-92-6/2-Amino-5-phosphonovalerate

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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