| Stimulation of the immune system by therapeutic antisense oligodeoxynucleotides and small interfering RNAs via nucleic acid receptors. | |
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MedLine Citation:
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PMID: 19796076 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Most of the therapeutic applications for synthetic oligodeoxynucleotides (ODN) and oligoribonucleotides (ORN) relate to mechanisms of manipulating gene expression based on Watson-Crick base pairing to endogenous nucleic acids. However, in recent years it has become apparent that the immune system has evolved defense mechanisms against infections that are based on the detection of infecting viral and bacterial nucleic acids. In some cases, synthetic ODN and ORN can trigger these defenses and, therefore, can interfere with or distort the mechanism of action of antisense ODN or small interfering RNAs. |
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Authors:
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Denise Richardt-Pargmann; Jörg Vollmer |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Annals of the New York Academy of Sciences Volume: 1175 ISSN: 1749-6632 ISO Abbreviation: Ann. N. Y. Acad. Sci. Publication Date: 2009 Sep |
Date Detail:
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Created Date: 2009-10-02 Completed Date: 2009-10-22 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 7506858 Medline TA: Ann N Y Acad Sci Country: United States |
Other Details:
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Languages: eng Pagination: 40-54 Citation Subset: IM |
Affiliation:
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Coley Pharmaceutical GmbH-A Pfizer Company, Düsseldorf, Germany. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adjuvants, Immunologic
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metabolism,
therapeutic use* Animals Cell Line, Tumor Immune System* Mice Neoplasms / immunology, therapy* Oligodeoxyribonucleotides, Antisense / metabolism, therapeutic use* RNA, Small Interfering / metabolism, therapeutic use* Receptors, Cell Surface / metabolism* Xenograft Model Antitumor Assays |
| Chemical | |
Reg. No./Substance:
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0/Adjuvants, Immunologic; 0/Oligodeoxyribonucleotides, Antisense; 0/RNA, Small Interfering; 0/Receptors, Cell Surface |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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