Document Detail

Stimulation of human lymphocytes by Herpes simplex virus antigens.
MedLine Citation:
PMID:  163788     Owner:  NLM     Status:  MEDLINE    
Lymphocytes from individuals with laboratory evidence of prior infection with herpes simplex virus (HSV) type 1 or type 2 demonstrated transformation (av antigens. Higher stimulation indexes were obtained when lymphocytes were incubated with the homologous as compared with the heterologous antigen. Higher mean lymphocyte stimulation indexes were also demonstrated in seropositive as compared with seronegative individuals. Lymphocytes from children with HSV-1 stomatitis usually became responsive to HSV-1 antigen within 2 to 6 weeks after the onset of illness. Lymphocytes from infants with neonatal HSV-2 infection were stimulated by HSV-2 antigen.
S E Starr; S A Karatela; S L Shore; A Duffey; A J Nahmias
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Publication Detail:
Type:  Journal Article; Research Support, U.S. Gov't, Non-P.H.S.; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Infection and immunity     Volume:  11     ISSN:  0019-9567     ISO Abbreviation:  Infect. Immun.     Publication Date:  1975 Jan 
Date Detail:
Created Date:  1975-06-11     Completed Date:  1975-06-11     Revised Date:  2009-11-18    
Medline Journal Info:
Nlm Unique ID:  0246127     Medline TA:  Infect Immun     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  109-12     Citation Subset:  IM    
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MeSH Terms
Antibodies, Viral / analysis
Antigens, Viral*
Cell Line
Cells, Cultured
Child, Preschool
Fluorescent Antibody Technique
Herpesviridae Infections / immunology
Infant, Newborn
Lymphocyte Activation*
Lymphocytes / immunology
Neutralization Tests
Simplexvirus / immunology*
Stomatitis / immunology
Thymidine / metabolism
Reg. No./Substance:
0/Antibodies, Viral; 0/Antigens, Viral; 10028-17-8/Tritium; 50-89-5/Thymidine

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