| Stimulation of human fibroblast collagen synthesis in vitro by gamma-aminobutyric acid. | |
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MedLine Citation:
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PMID: 3593419 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Human buccal mucosa fibroblasts were exposed in culture to gamma-aminobutyric acid (GABA) and the areca alkaloid arecaidine. Both GABA and arecaidine stimulated collagen synthesis and proliferation in a concentration-dependent manner, with arecaidine consistently producing the greater stimulation. Prior exposure to GABA or arecaidine for 5 days caused the cells to become insensitive when challenged with either drug. |
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Authors:
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A Scutt; S Meghji; W Harvey |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Biochemical pharmacology Volume: 36 ISSN: 0006-2952 ISO Abbreviation: Biochem. Pharmacol. Publication Date: 1987 Apr |
Date Detail:
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Created Date: 1987-07-01 Completed Date: 1987-07-01 Revised Date: 2004-11-17 |
Medline Journal Info:
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Nlm Unique ID: 0101032 Medline TA: Biochem Pharmacol Country: ENGLAND |
Other Details:
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Languages: eng Pagination: 1333-5 Citation Subset: IM |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Arecoline
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analogs & derivatives,
pharmacology Cell Division / drug effects Cells, Cultured Collagen / biosynthesis* Fibroblasts / metabolism Humans gamma-Aminobutyric Acid / pharmacology* |
| Chemical | |
Reg. No./Substance:
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499-04-7/arecaidine; 56-12-2/gamma-Aminobutyric Acid; 63-75-2/Arecoline; 9007-34-5/Collagen |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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