Document Detail


Stimulation of glycolysis by placental polypeptides and inhibition by duramycin.
MedLine Citation:
PMID:  6142764     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Placental polypeptides present in crude preparations of transforming growth factors stimulate glycolysis when added to quiescent 3T3 cells, normal rat kidney, and chick embryo fibroblasts. The stimulation was apparent over a time period of at least 90 min and was seen at glucose concentrations ranging from 1 to 30 mM. Duramycin, an antibiotic isolated from Streptomyces cinnamomeus, inhibits the polypeptide-stimulated and nonstimulated glycolysis of intact cells, since it permeabilizes cells to Pi and nucleotides. However, duramycin also inhibits the Na+-K+-ATPase as well as the ouabain-insensitive Mg2+-ATPase of plasma membranes. Duramycin has no effect on glycolysis catalyzed by cell-free extracts of Ehrlich ascites tumor cells in the presence of mitochondrial ATPase but partially inhibits glycolysis when ADP and Pi are generated by ATPases of plasma membrane preparations.
Authors:
E Racker; C Riegler; M Abdel-Ghany
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Cancer research     Volume:  44     ISSN:  0008-5472     ISO Abbreviation:  Cancer Res.     Publication Date:  1984 Apr 
Date Detail:
Created Date:  1984-05-04     Completed Date:  1984-05-04     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  2984705R     Medline TA:  Cancer Res     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  1364-7     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Adenosine Triphosphatases / antagonists & inhibitors
Animals
Anti-Bacterial Agents*
Bacteriocins
Ca(2+) Mg(2+)-ATPase
Carcinoma, Ehrlich Tumor / metabolism*
Cell Line
Cell Membrane / metabolism
Cells, Cultured
Chick Embryo
Dogs
Female
Glycolysis / drug effects
Growth Substances / pharmacology*
Humans
Kidney Medulla / enzymology
Lactates / metabolism
Lactic Acid
Mice
Microsomes / metabolism
Peptides / pharmacology
Pregnancy
Pregnancy Proteins / pharmacology*
Sodium-Potassium-Exchanging ATPase / antagonists & inhibitors
Chemical
Reg. No./Substance:
0/Anti-Bacterial Agents; 0/Bacteriocins; 0/Growth Substances; 0/Lactates; 0/Peptides; 0/Pregnancy Proteins; 1391-36-2/duramycin; 50-21-5/Lactic Acid; EC 3.6.1.-/Adenosine Triphosphatases; EC 3.6.1.-/Ca(2+) Mg(2+)-ATPase; EC 3.6.3.9/Sodium-Potassium-Exchanging ATPase

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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