Document Detail

Stimulation of glycolysis by placental polypeptides and inhibition by duramycin.
MedLine Citation:
PMID:  6142764     Owner:  NLM     Status:  MEDLINE    
Placental polypeptides present in crude preparations of transforming growth factors stimulate glycolysis when added to quiescent 3T3 cells, normal rat kidney, and chick embryo fibroblasts. The stimulation was apparent over a time period of at least 90 min and was seen at glucose concentrations ranging from 1 to 30 mM. Duramycin, an antibiotic isolated from Streptomyces cinnamomeus, inhibits the polypeptide-stimulated and nonstimulated glycolysis of intact cells, since it permeabilizes cells to Pi and nucleotides. However, duramycin also inhibits the Na+-K+-ATPase as well as the ouabain-insensitive Mg2+-ATPase of plasma membranes. Duramycin has no effect on glycolysis catalyzed by cell-free extracts of Ehrlich ascites tumor cells in the presence of mitochondrial ATPase but partially inhibits glycolysis when ADP and Pi are generated by ATPases of plasma membrane preparations.
E Racker; C Riegler; M Abdel-Ghany
Related Documents :
11351364 - Trigonella foenum graecum (fenugreek) seed extract as an antineoplastic agent.
185564 - Cell coat in tumor cells -- effects of trypsin and edta: a biochemical and morphologica...
10661864 - Fast control of dna replication in response to hypoxia and to inhibited protein synthes...
25470024 - The synthesis and antiproliferative activities of new arylidene-hydrazinyl-thiazole der...
17241774 - Cell cycle machinery and stroke.
12642874 - Requirement of the coiled-coil domains of p92(c-fes) for nuclear localization in myeloi...
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Cancer research     Volume:  44     ISSN:  0008-5472     ISO Abbreviation:  Cancer Res.     Publication Date:  1984 Apr 
Date Detail:
Created Date:  1984-05-04     Completed Date:  1984-05-04     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  2984705R     Medline TA:  Cancer Res     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  1364-7     Citation Subset:  IM    
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Adenosine Triphosphatases / antagonists & inhibitors
Anti-Bacterial Agents*
Ca(2+) Mg(2+)-ATPase
Carcinoma, Ehrlich Tumor / metabolism*
Cell Line
Cell Membrane / metabolism
Cells, Cultured
Chick Embryo
Glycolysis / drug effects
Growth Substances / pharmacology*
Kidney Medulla / enzymology
Lactates / metabolism
Lactic Acid
Microsomes / metabolism
Peptides / pharmacology
Pregnancy Proteins / pharmacology*
Sodium-Potassium-Exchanging ATPase / antagonists & inhibitors
Reg. No./Substance:
0/Anti-Bacterial Agents; 0/Bacteriocins; 0/Growth Substances; 0/Lactates; 0/Peptides; 0/Pregnancy Proteins; 1391-36-2/duramycin; 50-21-5/Lactic Acid; EC 3.6.1.-/Adenosine Triphosphatases; EC 3.6.1.-/Ca(2+) Mg(2+)-ATPase; EC ATPase

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  Effect of hexachlorobenzene on male and female rat hepatic gamma-glutamyl transpeptidase levels.
Next Document:  Prevention of growth of leukemia cells in mice by monoclonal antibodies directed against Thy 1.1 ant...