Document Detail

Stimulation of gastric acid secretion by centrally administered orexin-A in conscious rats.
MedLine Citation:
PMID:  9920789     Owner:  NLM     Status:  MEDLINE    
Orexins are novel neuropeptides that are localized in neurons within the lateral hypothalamus and regulate feeding behavior. The lateral hypothalamus also plays an important role in the central regulation of gut function. We therefore hypothesized that orexins might be involved in the central control of gastric acid secretion. To address this question, we examined the effect of central injection of orexins on gastric acid secretion in rats. Intracisternal injection of synthetic orexin-A but not orexin-B dose-dependently stimulated acid secretion while intraperitoneal administration of orexin-A failed to stimulate acid secretion. Vagotomy or atropine abolished the action by central orexin-A. These data suggest for the first time that orexin-A may act in the brain to stimulate gastric acid secretion by modulating the vagal system. Considering its stimulatory action on feeding, we hypothesize here that orexin-A is a candidate mediator of cephalic phase gastric secretion.
N Takahashi; T Okumura; H Yamada; Y Kohgo
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Biochemical and biophysical research communications     Volume:  254     ISSN:  0006-291X     ISO Abbreviation:  Biochem. Biophys. Res. Commun.     Publication Date:  1999 Jan 
Date Detail:
Created Date:  1999-03-01     Completed Date:  1999-03-01     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0372516     Medline TA:  Biochem Biophys Res Commun     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  623-7     Citation Subset:  IM    
Copyright Information:
Copyright 1999 Academic Press.
Third Department of Internal Medicine, Asahikawa Medical College, 4-5 Asahikawa, Hokkaido, 078-8307, Japan.
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MeSH Terms
Carrier Proteins / administration & dosage,  pharmacology*
Gastric Acid / secretion*
Gastric Mucosa / drug effects*,  secretion
Injections, Intravenous
Intracellular Signaling Peptides and Proteins*
Neuropeptides / administration & dosage,  pharmacology*
Rats, Sprague-Dawley
Recombinant Proteins / administration & dosage,  pharmacology
Reg. No./Substance:
0/Carrier Proteins; 0/Intracellular Signaling Peptides and Proteins; 0/Neuropeptides; 0/Recombinant Proteins; 0/orexins

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