Document Detail

Stimulation of eating by the second messenger cAMP in the perifornical and lateral hypothalamus.
MedLine Citation:
PMID:  9249539     Owner:  NLM     Status:  MEDLINE    
Despite intense study of neurotransmitters mediating hypothalamic controls of food intake, little is known about which second messengers are critical for these mechanisms. To determine whether adenosine 3',5'-cyclic monophosphate (cAMP) might participate in these mechanisms, we injected the membrane-permeant cAMP analog 8-bromo-cAMP (8-BrcAMP) hypothalamically in satiated rats. Injection of 8-BrcAMP (10-100 nmol) into the perifornical (PFH) and lateral hypothalamus (LH) dose dependently stimulated food intake of up to 15.7 g in 2 h. Significantly smaller responses were obtained with thalamic injections. In contrast to the strong stimulatory effects of PFH and LH 8-BrcAMP, cAMP and 8-bromo-guanosine 3',5'-cyclic monophosphate (100 nmol) were ineffective, suggesting a chemically specific, intracellular action. Consistent with this, combined PFH injection of 7-deacetyl-7-O-(N-methylpiperazino)-tau-butyryl-forskolin dihydrochloride and 3-isobutyl-1-methylxanthine, agents that increase endogeneous cAMP, stimulated eating of up to 9.9 g in 2 h. These results demonstrate that increases in PFH/LH cAMP can elicit complex, goal-oriented behavior, suggesting an important role for cAMP in hypothalamic mechanisms stimulating food intake.
E R Gillard; A M Khan; Ahsan-ul-Haq; R S Grewal; B Mouradi; B G Stanley
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  The American journal of physiology     Volume:  273     ISSN:  0002-9513     ISO Abbreviation:  Am. J. Physiol.     Publication Date:  1997 Jul 
Date Detail:
Created Date:  1997-09-03     Completed Date:  1997-09-03     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  0370511     Medline TA:  Am J Physiol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  R107-12     Citation Subset:  IM    
Department of Neuroscience, University of California at Riverside 92521, USA.
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MeSH Terms
1-Methyl-3-isobutylxanthine / administration & dosage,  pharmacology
8-Bromo Cyclic Adenosine Monophosphate / administration & dosage,  pharmacology*
Cyclic AMP / physiology*
Cyclic GMP / administration & dosage,  analogs & derivatives,  pharmacology
Eating / physiology*
Forskolin / administration & dosage,  analogs & derivatives,  pharmacology
Hypothalamic Area, Lateral / drug effects,  physiology*
Neurons / drug effects,  physiology*
Paraventricular Hypothalamic Nucleus / drug effects,  physiology*
Rats, Sprague-Dawley
Second Messenger Systems / physiology*
Stereotaxic Techniques
Thalamus / drug effects,  physiology
Grant Support
Reg. No./Substance:
110452-75-0/L 858051; 23583-48-4/8-Bromo Cyclic Adenosine Monophosphate; 28822-58-4/1-Methyl-3-isobutylxanthine; 31356-94-2/8-bromocyclic GMP; 60-92-4/Cyclic AMP; 66428-89-5/Forskolin; 7665-99-8/Cyclic GMP

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