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Stimulation of contraction of pregnant rat uterus in vitro by non-dechlorinated and microbially dechlorinated mixtures of polychlorinated biphenyls.
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MedLine Citation:
PMID:  11333189     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
A previous study of six polychlorinated biphenyl (PCB) congeners showed that PCBs with four or fewer chlorines and ortho substitution stimulate uterine contraction frequency in vitro, whereas congeners with a greater number of chlorines or non-ortho substitution are inactive in vitro. We tested the hypothesis that PCB mixtures stimulate uterine contractions in a manner inversely related to the degree of chlorination and the presence of chlorines in the ortho- position of the biphenyl constituents of the mixtures. Uterine strips from pregnant rats were suspended in standard muscle baths and analyzed for changes in isometric contractions in response to in vitro exposure to commercial PCB mixtures (Aroclors) and their dechlorinated products after microbial degradation. The PCB mixtures Aroclor 1242, 1248, and 1254 significantly stimulated uterine contraction frequency, and the least chlorinated mixture, Aroclor 1242, was the most potent stimulant. Microbes from Hudson River sediment dechlorinated Aroclor 1242 and Aroclor 1254 under reducing conditions to produce mixtures with an increased proportion of ortho-substituted congeners with one or two chlorine substitutions. The PCB mixtures that had undergone microbial reductive dechlorination stimulated uterine contraction frequency to a significantly greater extent than the parent mixtures. These results show that increased uterotonic activity was associated with decreased chlorination and increased ortho substitution of the biphenyl constituents of the mixtures.
Authors:
J Bae; M A Mousa; J F Quensen; S A Boyd; R Loch-Caruso
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Publication Detail:
Type:  Journal Article; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Environmental health perspectives     Volume:  109     ISSN:  0091-6765     ISO Abbreviation:  Environ. Health Perspect.     Publication Date:  2001 Mar 
Date Detail:
Created Date:  2001-05-02     Completed Date:  2001-07-19     Revised Date:  2010-09-14    
Medline Journal Info:
Nlm Unique ID:  0330411     Medline TA:  Environ Health Perspect     Country:  United States    
Other Details:
Languages:  eng     Pagination:  275-82     Citation Subset:  IM    
Affiliation:
Toxicology Program, Department of Environmental Health Sciences, The University of Michigan, Ann Arbor, MI 48109-2029, USA.
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MeSH Terms
Descriptor/Qualifier:
Animals
Aroclors / chemistry,  pharmacology
Environmental Pollutants / pharmacology*
Female
Muscle Contraction / drug effects*
Polychlorinated Biphenyls / chemistry,  pharmacology*
Pregnancy
Rats
Structure-Activity Relationship
Uterus / drug effects*
Grant Support
ID/Acronym/Agency:
P30-HD18258/HD/NICHD NIH HHS; P42-ES04911/ES/NIEHS NIH HHS
Chemical
Reg. No./Substance:
0/Aroclors; 0/Environmental Pollutants; 0/Polychlorinated Biphenyls
Comments/Corrections

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Full Text
Journal Information
Journal ID (nlm-ta): Environ Health Perspect
ISSN: 0091-6765
Article Information
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Print publication date: Month: 3 Year: 2001
Volume: 109 Issue: 3
First Page: 275 Last Page: 282
ID: 1240246
PubMed Id: 11333189
Publisher Item Identifier: sc271_5_1835

Stimulation of contraction of pregnant rat uterus in vitro by non-dechlorinated and microbially dechlorinated mixtures of polychlorinated biphenyls.
J Bae
M A Mousa
J F Quensen, 3rd
S A Boyd
R Loch-Caruso
Toxicology Program, Department of Environmental Health Sciences, The University of Michigan, Ann Arbor, MI 48109-2029, USA.


Article Categories:
  • Research Article


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