Document Detail

Stimulation of collateral artery growth: travelling further down the road to clinical application.
MedLine Citation:
PMID:  19144878     Owner:  NLM     Status:  MEDLINE    
Collateral artery growth is a potent natural defence mechanism to prevent death and myocardial infarction in occlusive artery disease. Given the high prevalence of arterial obstructive disease, a therapeutic compound stimulating collateral vessel growth could have a major impact on morbidity and mortality world wide. Although experimental studies on the stimulation of arteriogenesis have been promising, not a single drug has been proved to be applicable in clinical practice, either because of lack of efficacy or because of undesired side effects. This review summarises current knowledge on the mechanisms of collateral artery growth and examines problems that arise from the clinical implementation of pro-arteriogenic treatments to date. Future directions in the translation from bench to bedside and potential new approaches to the stimulation of vascular growth are discussed.
S H Schirmer; F C van Nooijen; J J Piek; N van Royen
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Review    
Journal Detail:
Title:  Heart (British Cardiac Society)     Volume:  95     ISSN:  1468-201X     ISO Abbreviation:  Heart     Publication Date:  2009 Mar 
Date Detail:
Created Date:  2009-01-15     Completed Date:  2009-04-09     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9602087     Medline TA:  Heart     Country:  England    
Other Details:
Languages:  eng     Pagination:  191-7     Citation Subset:  AIM; IM    
Department of Cardiology, Academic Medical Centre, Meibergdreef 9, 1105 AZ Amsterdam, The Netherlands.
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MeSH Terms
Angiogenesis Inducing Agents / therapeutic use*
Arterial Occlusive Diseases / drug therapy*,  physiopathology
Cell Proliferation / drug effects
Clinical Trials as Topic
Collateral Circulation* / physiology
Endothelium, Vascular / physiology
Granulocyte-Macrophage Colony-Stimulating Factor / therapeutic use*
Hemorheology / physiology
Myocytes, Smooth Muscle / physiology
Neovascularization, Physiologic*
Reg. No./Substance:
0/Angiogenesis Inducing Agents; 83869-56-1/Granulocyte-Macrophage Colony-Stimulating Factor

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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