| Stimulation of collateral artery growth: travelling further down the road to clinical application. | |
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MedLine Citation:
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PMID: 19144878 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Collateral artery growth is a potent natural defence mechanism to prevent death and myocardial infarction in occlusive artery disease. Given the high prevalence of arterial obstructive disease, a therapeutic compound stimulating collateral vessel growth could have a major impact on morbidity and mortality world wide. Although experimental studies on the stimulation of arteriogenesis have been promising, not a single drug has been proved to be applicable in clinical practice, either because of lack of efficacy or because of undesired side effects. This review summarises current knowledge on the mechanisms of collateral artery growth and examines problems that arise from the clinical implementation of pro-arteriogenic treatments to date. Future directions in the translation from bench to bedside and potential new approaches to the stimulation of vascular growth are discussed. |
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Authors:
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S H Schirmer; F C van Nooijen; J J Piek; N van Royen |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't; Review |
Journal Detail:
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Title: Heart (British Cardiac Society) Volume: 95 ISSN: 1468-201X ISO Abbreviation: Heart Publication Date: 2009 Mar |
Date Detail:
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Created Date: 2009-01-15 Completed Date: 2009-04-09 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 9602087 Medline TA: Heart Country: England |
Other Details:
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Languages: eng Pagination: 191-7 Citation Subset: AIM; IM |
Affiliation:
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Department of Cardiology, Academic Medical Centre, Meibergdreef 9, 1105 AZ Amsterdam, The Netherlands. Stephan.schirmer@uks.eu |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Angiogenesis Inducing Agents
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therapeutic use* Animals Arterial Occlusive Diseases / drug therapy*, physiopathology Cell Proliferation / drug effects Clinical Trials as Topic Collateral Circulation* / physiology Endothelium, Vascular / physiology Female Granulocyte-Macrophage Colony-Stimulating Factor / therapeutic use* Hemorheology / physiology Humans Male Myocytes, Smooth Muscle / physiology Neovascularization, Physiologic* |
| Chemical | |
Reg. No./Substance:
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0/Angiogenesis Inducing Agents; 83869-56-1/Granulocyte-Macrophage Colony-Stimulating Factor |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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