Document Detail

Stimulation of collateral artery growth: a potential treatment for peripheral artery disease.
MedLine Citation:
PMID:  15225117     Owner:  NLM     Status:  MEDLINE    
In the course of peripheral artery occlusive disease, blood flow to peripheral tissue progressively decreases in a substantial portion of patients, leading to insufficient oxygenation and to the occurrence of claudication or critical limb ischemia. Arteriogenesis (collateral artery growth) is a powerful natural mechanism by which large conductance vessels develop that circumvent sites of obstruction. Promising experimental data on both hypoxia-driven angiogenesis as well as monocyte-orchestrated arteriogenesis have raised high hopes for clinical application. Both endothelial growth factors to stimulate angiogenesis (i.e., capillary growth) and monocyte-attracting or -activating substances to stimulate arteriogenesis, have been proposed as potential new therapeutic agents. However, transferring the promising experimental results into clinical practice has been more cumbersome than initially anticipated. Some recent clinical studies are now focusing more specifically on the stimulation of arteriogenesis. This review will critically evaluate the results of preclinical and clinical investigations on the stimulation of vascular growth, focusing specifically on the peripheral circulation.
Stephan H Schirmer; Niels van Royen
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Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  Expert review of cardiovascular therapy     Volume:  2     ISSN:  1744-8344     ISO Abbreviation:  Expert Rev Cardiovasc Ther     Publication Date:  2004 Jul 
Date Detail:
Created Date:  2004-06-30     Completed Date:  2007-10-05     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101182328     Medline TA:  Expert Rev Cardiovasc Ther     Country:  England    
Other Details:
Languages:  eng     Pagination:  581-8     Citation Subset:  IM    
Department of Internal Medicine III-Cardiology and Angiology, University Hospital Freiburg, Germany.
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MeSH Terms
Arterial Occlusive Diseases / etiology,  physiopathology,  therapy*
Collateral Circulation / physiology*
Fibroblast Growth Factor 2 / physiology
Gene Transfer Techniques
Peripheral Vascular Diseases / etiology,  physiopathology,  therapy*
Vascular Endothelial Growth Factor A / physiology
Reg. No./Substance:
0/Vascular Endothelial Growth Factor A; 103107-01-3/Fibroblast Growth Factor 2

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