Document Detail

Stimulation of cell growth and DNA synthesis by peripheral benzodiazepine.
MedLine Citation:
PMID:  2155058     Owner:  NLM     Status:  MEDLINE    
The effects of peripheral benzodiazepine receptor ligands on cell proliferation were evaluated. PK11195 increased the growth rate of C6 glioma cells by 20-30% in the nanomolar range in serum free medium. [3H]thymidine incorporation into C6 glioma cells also were increased 22% and 25% after treatment by PK11195 and Ro5-4864, respectively. The effect of PK11195 as a mitogenic agent was estimated by mitogenic agent was estimated by [3H]thymidine incorporation using Swiss 3T3 cells. PK11195 increased DNA synthesis 170% over control at 10 nM. Higher concentrations of benzodiazepines showed inhibition of the DNA synthesis. Peripheral benzodiazepine binding sites underwent downregulation after exposure to serum free medium or to 10 nM PK11195. These findings suggest that peripheral benzodiazepines may be involved in the regulation of cell proliferation as a growth factor in lower concentration and as a antiproliferative agent in higher concentration.
K Ikezaki; K L Black
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Cancer letters     Volume:  49     ISSN:  0304-3835     ISO Abbreviation:  Cancer Lett.     Publication Date:  1990 Feb 
Date Detail:
Created Date:  1990-03-30     Completed Date:  1990-03-30     Revised Date:  2008-11-21    
Medline Journal Info:
Nlm Unique ID:  7600053     Medline TA:  Cancer Lett     Country:  NETHERLANDS    
Other Details:
Languages:  eng     Pagination:  115-20     Citation Subset:  IM    
Jonsson Cancer Center, Division of Neurosurgery, UCLA School of Medicine 90024.
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MeSH Terms
Benzodiazepines / pharmacology*
Benzodiazepinones / pharmacology
Cell Division / drug effects*
Cell Line
DNA Replication / drug effects*
DNA, Neoplasm / drug effects
Down-Regulation / drug effects
Glioma / genetics,  pathology
Isoquinolines / pharmacology
Receptors, GABA-A / drug effects
Thymidine / metabolism
Tumor Cells, Cultured
Grant Support
Reg. No./Substance:
0/Benzodiazepinones; 0/DNA, Neoplasm; 0/Isoquinolines; 0/Receptors, GABA-A; 12794-10-4/Benzodiazepines; 14439-61-3/4'-chlorodiazepam; 50-89-5/Thymidine; 85340-56-3/PK 11195

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