Document Detail

Stimulation by urocortin of growth hormone (GH) secretion in GH-producing human pituitary adenoma cells.
MedLine Citation:
PMID:  9447301     Owner:  NLM     Status:  MEDLINE    
Urocortin (Ucn) possesses high homology with CRH and is considered to be a ligand to type-2 CRH receptor. We investigated the effect of Ucn on hormone release from cultured GH-producing human pituitary adenoma cells in vitro. GH-producing human pituitary adenoma cells were superfused on a Sephadex G-25 column. Both Ucn (10 nM) and CRH (10 nM) elicited an increase in GH release from the pituitary adenoma cells in one patient with acromegaly. In contrast, GH release from the pituitary adenoma cells was stimulated by Ucn but not by CRH in the other patient with acromegaly. These preliminary findings suggest that type-2 CRH receptors are expressed in some population of GH-producing human pituitary adenoma cells and that Ucn might be involved in GH secretion from tumorous tissues in patients with acromegaly.
Y Murakami; T Mori; K Koshimura; M Kurosaki; T Hori; N Yanaihara; Y Kato
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Endocrine journal     Volume:  44     ISSN:  0918-8959     ISO Abbreviation:  Endocr. J.     Publication Date:  1997 Aug 
Date Detail:
Created Date:  1998-03-13     Completed Date:  1998-03-13     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  9313485     Medline TA:  Endocr J     Country:  JAPAN    
Other Details:
Languages:  eng     Pagination:  627-9     Citation Subset:  IM    
Department of Medicine, Shimane Medical University, Izumo, Japan.
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MeSH Terms
Adenoma / pathology,  secretion*
Corticotropin-Releasing Hormone / pharmacology*
Human Growth Hormone / secretion*
Middle Aged
Pituitary Neoplasms / pathology,  secretion*
Secretory Rate / drug effects
Stimulation, Chemical
Tumor Cells, Cultured
Reg. No./Substance:
0/Urocortins; 12629-01-5/Human Growth Hormone; 9015-71-8/Corticotropin-Releasing Hormone

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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