Document Detail

Stimulation by prostaglandin F2 alpha of phosphatidic acid-phosphatidylinositol turnover in rat luteal cells.
MedLine Citation:
PMID:  6357198     Owner:  NLM     Status:  MEDLINE    
Prostaglandin F2 alpha (PGF 2 alpha) causes a rapid and marked increase of [32P]-orthophosphate incorporation into phosphatidylinositol (PI) and phosphatidic acid (PA) in rat luteal cells in culture. The incorporation of radioactivity is increased as early as 2 and 5 min after PGF 2 alpha addition into PA and PI, respectively, and by 10 min has reached a 2-fold stimulation over control in both lipid moieties. The labeling of other phospholipids is not affected. PGF 2 alpha exerts its stimulatory effect at an ED50 value of approximately 200 and 60 nM on PI and PA labeling, respectively. By contrast, human chorionic gonadotropin has no effect alone and does not interfere with the PGF 2 alpha-induced stimulation of PA-PI labeling. The striking similarity between the effects of PGF 2 alpha and LHRH on PA-PI labeling suggests that the two agents may exert their direct action on the corpus luteum via a common intracellular mechanism involving acidic phospholipid metabolism.
V Raymond; P C Leung; F Labrie
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Biochemical and biophysical research communications     Volume:  116     ISSN:  0006-291X     ISO Abbreviation:  Biochem. Biophys. Res. Commun.     Publication Date:  1983 Oct 
Date Detail:
Created Date:  1983-12-17     Completed Date:  1983-12-17     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0372516     Medline TA:  Biochem Biophys Res Commun     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  39-46     Citation Subset:  IM    
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MeSH Terms
Cells, Cultured
Chorionic Gonadotropin / pharmacology
Corpus Luteum / metabolism*
Dose-Response Relationship, Drug
Gonadotropin-Releasing Hormone / pharmacology
Phosphatidic Acids / metabolism*
Phosphatidylinositols / metabolism*
Prostaglandins F / pharmacology*
Reg. No./Substance:
0/Chorionic Gonadotropin; 0/Phosphatidic Acids; 0/Phosphatidylinositols; 0/Prostaglandins F; 33515-09-2/Gonadotropin-Releasing Hormone; 551-11-1/Dinoprost

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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