Document Detail

Stimulation by adrenaline and dopamine but not by noradrenaline of myocardial alpha-adrenoceptors mediating positive inotropic effects in human atrial preparations.
MedLine Citation:
PMID:  6248799     Owner:  NLM     Status:  MEDLINE    
In isolated electrically driven right auricular strips of human hearts (1 Hz at 37 degrees C) the ability of the endogenous catecholamines noradrenaline, adrenaline, and dopamine to mediate positive inotropic effects by stimulation of myocardial alpha-adrenoceptors was investigated. 1. The concentration-response curve for the positive inotropic effect of noradrenaline was shifted to the right by pindolol, 10(-8)M, whereas the additional blockade by phentolamine, 3 x 10(-6)M, was without further effect; therefore, the positive inotropic effect of noradrenaline is mediated by beta-adrenoceptors only. 2. In contrast, the positive inotropic effects of adrenaline as well as of dopamine are caused by stimulation of both, beta- and alpha-adrenoceptors. 3. These results are discussed with respect to the possible physiological and pathophysiological function of myocardial alpha-adrenoceptors.
J Wagner; H J Schümann; A Knorr; N Rohm; J C Reidemeister
Related Documents :
22105969 - Clinical outcomes and predictors of unprotected left main stem culprit lesions in patie...
9706829 - Very early administration of ace-inhibitors in acute myocardial infarction.
1378149 - Use of multiple-action agents on the heart: pathophysiological and therapeutic consider...
21940729 - Aldosterone and cortisol predict medium-term left ventricular remodelling following myo...
21888129 - Atrial fibrillation: diagnosis and treatment.
10908079 - Electrophysiological changes of angiotensin-converting enzyme inhibition after myocardi...
23803239 - Percutaneous ventricular assist device and extracorporeal membrane oxygenation support ...
11839889 - Innovative endovascular defibrillator lead use in superior vena cava obstruction.
22806909 - Sulfur dioxide restores calcium homeostasis disturbance in rat with isoproterenol-induc...
Publication Detail:
Type:  In Vitro; Journal Article    
Journal Detail:
Title:  Naunyn-Schmiedeberg's archives of pharmacology     Volume:  312     ISSN:  0028-1298     ISO Abbreviation:  Naunyn Schmiedebergs Arch. Pharmacol.     Publication Date:  1980 May 
Date Detail:
Created Date:  1980-09-23     Completed Date:  1980-09-23     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0326264     Medline TA:  Naunyn Schmiedebergs Arch Pharmacol     Country:  GERMANY, WEST    
Other Details:
Languages:  eng     Pagination:  99-102     Citation Subset:  IM    
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Catecholamines / pharmacology*
Dopamine / pharmacology
Epinephrine / pharmacology
Heart / drug effects*
Myocardial Contraction / drug effects*
Norepinephrine / pharmacology
Receptors, Adrenergic / drug effects*
Receptors, Adrenergic, alpha / drug effects*
Stimulation, Chemical
Reg. No./Substance:
0/Catecholamines; 0/Receptors, Adrenergic; 0/Receptors, Adrenergic, alpha; 51-41-2/Norepinephrine; 51-43-4/Epinephrine

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  Central blood pressure effects of guanylyl-imido-diphosphate and cyclic guanosine-monophosphate.
Next Document:  Characterization of tumors induced in adult Macaca mulata monkeys with Carr-Zilber strain of Rous sa...