Document Detail

Stimulation by adrenaline and dopamine but not by noradrenaline of myocardial alpha-adrenoceptors mediating positive inotropic effects in human atrial preparations.
MedLine Citation:
PMID:  6248799     Owner:  NLM     Status:  MEDLINE    
In isolated electrically driven right auricular strips of human hearts (1 Hz at 37 degrees C) the ability of the endogenous catecholamines noradrenaline, adrenaline, and dopamine to mediate positive inotropic effects by stimulation of myocardial alpha-adrenoceptors was investigated. 1. The concentration-response curve for the positive inotropic effect of noradrenaline was shifted to the right by pindolol, 10(-8)M, whereas the additional blockade by phentolamine, 3 x 10(-6)M, was without further effect; therefore, the positive inotropic effect of noradrenaline is mediated by beta-adrenoceptors only. 2. In contrast, the positive inotropic effects of adrenaline as well as of dopamine are caused by stimulation of both, beta- and alpha-adrenoceptors. 3. These results are discussed with respect to the possible physiological and pathophysiological function of myocardial alpha-adrenoceptors.
J Wagner; H J Schümann; A Knorr; N Rohm; J C Reidemeister
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Publication Detail:
Type:  In Vitro; Journal Article    
Journal Detail:
Title:  Naunyn-Schmiedeberg's archives of pharmacology     Volume:  312     ISSN:  0028-1298     ISO Abbreviation:  Naunyn Schmiedebergs Arch. Pharmacol.     Publication Date:  1980 May 
Date Detail:
Created Date:  1980-09-23     Completed Date:  1980-09-23     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0326264     Medline TA:  Naunyn Schmiedebergs Arch Pharmacol     Country:  GERMANY, WEST    
Other Details:
Languages:  eng     Pagination:  99-102     Citation Subset:  IM    
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MeSH Terms
Catecholamines / pharmacology*
Dopamine / pharmacology
Epinephrine / pharmacology
Heart / drug effects*
Myocardial Contraction / drug effects*
Norepinephrine / pharmacology
Receptors, Adrenergic / drug effects*
Receptors, Adrenergic, alpha / drug effects*
Stimulation, Chemical
Reg. No./Substance:
0/Catecholamines; 0/Receptors, Adrenergic; 0/Receptors, Adrenergic, alpha; 51-41-2/Norepinephrine; 51-43-4/Epinephrine

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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